Key Documents

View All Documentation

426016

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione

Name: 4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione
Brand: ALDRICH

99%

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₈H₅F₃O₃

CAS Number:

326-90-9

Molecular Weight:

206.12

NACRES:

NA.22

PubChem Substance ID:

24866679

UNSPSC Code:

12352100

EC Number:

206-315-1

MDL number:

MFCD00020935

Assay:

99%

Form:

liquid

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Level

100

assay

99%

form

liquid

refractive index

n20/D 1.528 (lit.)

bp

203 °C (lit.)

mp

19-21 °C (lit.)

density

1.391 g/mL at 25 °C (lit.)

functional group

fluoro, ketone

storage temp.

2-8°C

SMILES string

FC(F)(F)C(=O)CC(=O)c1ccco1

InChI

1S/C8H5F3O3/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2

InChI key

OWLPCALGCHDBCN-UHFFFAOYSA-N

Description

General description

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (furoyltrifluoroacetone, FTFA) is a β-diketone. Its cytotoxic activity against human cultured tumor and normal cells has been evaluated. Reports suggest that 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione partially inhibits the oxidation of ferrocyanide in ETP (electron transport particles) isolated from beef heart mitochondria. Its reaction with N,N,N′,N′-tetramethylalkyl diamines to form ionic adducts has been investigated. The conformational analysis of the enol and keto form of FTFA has been reported.

Application

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (tfa) may be used in the following studies:

As capping ligand in the synthesis of [Eu(tfa)₃]₂bpm complexes (bpm=2,2′-bipyrimidine).
As reagent in the multistep synthesis of [¹³CD₂]benzylamine.
As reagent in the synthesis of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives by reacting with corresponding benzofurazan oxides.
In the efficient syntheses of perfluoroalkyl substituted azoles.
Synthesis of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Topography of the cristae membrane as elucidated by a new inhibitor, trifluorofurylbutanedione.

H J Harmon et al.

Biochemical and biophysical research communications, 55(1), 169-173 (1973-11-01)

Acyclic tertiary diamines and 1, 4, 7,10-tetraazacyclododecane with fluorine-containing β-diketones: Leading to low melting ionic adducts.

Gupta OD, et al.

Journal of Fluorine Chemistry, 126(8), 1222-1229 (2005)

Antiplasmodial structure-activity relationship of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives.

Adoración Marin et al.

Experimental parasitology, 118(1), 25-31 (2007-07-07)

Derivatives of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide (4b-g, 5b-g, 6a-g) were synthesized and evaluated for their capacity to inhibit the growth of chloroquine-resistant Plasmodium falciparum FCB1 strain in culture. Compound 7-chloro-2-(2-furylcarbonyl)-3-trifluoromethyl-1,4-quinoxaline di-N-oxide (5g) was the most active being almost 5 times more active

View All Related Papers

Global Trade Item Number

SKU	GTIN
426016-1G	04061837714535