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426016

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione

Name: 4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione
Brand: ALDRICH

99%

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About This Item

Empirical Formula (Hill Notation):

C₈H₅F₃O₃

CAS Number:

326-90-9

Molecular Weight:

206.12

NACRES:

NA.22

PubChem Substance ID:

24866679

UNSPSC Code:

12352100

EC Number:

206-315-1

MDL number:

MFCD00020935

Assay:

99%

Form:

liquid

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Properties

Quality Segment

100

assay

99%

form

liquid

refractive index

n20/D 1.528 (lit.)

bp

203 °C (lit.)

mp

19-21 °C (lit.)

density

1.391 g/mL at 25 °C (lit.)

functional group

fluoro, ketone

storage temp.

2-8°C

SMILES string

FC(F)(F)C(=O)CC(=O)c1ccco1

InChI

1S/C8H5F3O3/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2

InChI key

OWLPCALGCHDBCN-UHFFFAOYSA-N

Description

General description

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (furoyltrifluoroacetone, FTFA) is a β-diketone. Its cytotoxic activity against human cultured tumor and normal cells has been evaluated. Reports suggest that 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione partially inhibits the oxidation of ferrocyanide in ETP (electron transport particles) isolated from beef heart mitochondria. Its reaction with N,N,N′,N′-tetramethylalkyl diamines to form ionic adducts has been investigated. The conformational analysis of the enol and keto form of FTFA has been reported.

Application

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (tfa) may be used in the following studies:

As capping ligand in the synthesis of [Eu(tfa)₃]₂bpm complexes (bpm=2,2′-bipyrimidine).
As reagent in the multistep synthesis of [¹³CD₂]benzylamine.
As reagent in the synthesis of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives by reacting with corresponding benzofurazan oxides.
In the efficient syntheses of perfluoroalkyl substituted azoles.
Synthesis of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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