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Merck
CN

437395

Sigma-Aldrich

2-Ethylhexyl 4-(dimethylamino)benzoate

98%

Synonym(s):

2-Ethylhexyl 4-(N ,N -dimethylamino)benzoate, 2-Ethylhexyl 4-(dimethylamino)benzoate, 2-Ethylhexyl N ,N -dimethyl-p -aminobenzoate, 2-Ethylhexyl p -(dimethylamino)benzoate, 4-(Dimethylamino)benzoic acid 2-ethylhexyl ester, EHDAB, Octyl dimethyl PABA

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About This Item

Linear Formula:
(CH3)2NC6H4CO2CH2CH(C2H5)(CH2)3CH3
CAS Number:
Molecular Weight:
277.40
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
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Assay

98%

form

liquid

refractive index

n20/D 1.542 (lit.)

bp

325 °C (lit.)

density

0.995 g/mL at 25 °C (lit.)

SMILES string

CCCCC(CC)COC(=O)c1ccc(cc1)N(C)C

InChI

1S/C17H27NO2/c1-5-7-8-14(6-2)13-20-17(19)15-9-11-16(12-10-15)18(3)4/h9-12,14H,5-8,13H2,1-4H3

InChI key

WYWZRNAHINYAEF-UHFFFAOYSA-N

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General description

2-Ethylhexyl 4-(dimethylamino)benzoate is an organic UV filter widely used in the preparation of sunscreens and ultrathin films of acrylates.

Application

  • Study of the photochemical transformation of 2-ethylhexyl 4-(dimethylamino) benzoate (OD-PABA) under conditions relevant to surface waters: This research investigates the photochemical behavior and transformation products of 2-ethylhexyl 4-(dimethylamino)benzoate in aquatic environments, highlighting its environmental impact (Calza et al., 2016).
  • Photoprotection or photodamage: a direct observation of nonradiative dynamics from 2-ethylhexyl 4-dimethylaminobenzoate sunscreen agent: The paper provides insights into the nonradiative dynamics of 2-ethylhexyl 4-dimethylaminobenzoate, assessing its effectiveness as a sunscreen agent and potential for photodamage (Ma et al., 2018).
  • Bioaccumulation and biomagnification of 2-ethylhexyl-4-dimethylaminobenzoate in aquatic animals: This study examines the bioaccumulation and biomagnification potential of 2-ethylhexyl-4-dimethylaminobenzoate in aquatic organisms, providing valuable data on its environmental persistence and effects (Lu et al., 2018).

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

374.0 °F - closed cup

Flash Point(C)

190 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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T M Morgan et al.
Journal of pharmaceutical sciences, 87(10), 1219-1225 (1998-10-06)
This study investigated the enhanced transdermal delivery of testosterone (Tes) and estradiol (E2) in swine in vivo with novel metered-dose topical aerosols containing the penetration enhancer padimate O (PadO) and predicted the dose deliverable in humans from the calculated drug
S Scalia et al.
The Journal of pharmacy and pharmacology, 51(12), 1367-1374 (2000-03-04)
The interaction between the UV filter, 2-ethylhexyl-p-dimethylaminobenzoate, and unmodified and modified alpha-, beta- or gamma-cyclodextrins was studied in water by phase-solubility analysis. Of the cyclodextrins available, only hydroxypropyl-beta-cyclodextrin caused a marked increase in the aqueous solubility of 2-ethylhexyl-p-dimethylaminobenzoate. The data
J Knowland et al.
FEBS letters, 324(3), 309-313 (1993-06-21)
We have tested the mutagenicity of a UV-B sunscreen ingredient called Padimate-O or octyl dimethyl PABA, which, chemically speaking, is identical to an industrial chemical that generates free radicals when illuminated. It is harmless in the dark but mutagenic in
Yi-Hung Tsai et al.
International journal of pharmaceutics, 388(1-2), 257-262 (2010-01-12)
Hesperetin is one of the flavonoids and possess anti-inflammatory, UV-protecting and antioxidant effects. Permeation issues for topical delivery systems of such effects are occasionally problematic, and in view of the fact that microemulsions are potential carriers for transdermal delivery system
Gamal M M El Maghraby et al.
International journal of pharmaceutics, 305(1-2), 90-104 (2005-10-04)
Employing thermal analysis, we investigated the mechanism of action of novel enhancers and probed phospholipid (PL) versus stratum corneum lipid (SCL) liposomes as model membranes. The enhancers included octyl salicylate (OS), padimate O (PADO) and 2-(1-nonyl)-1,3-dioxolane (ND). The negative controls

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