2,2′-Azobis(2-methylpropionamidine) dihydrochloride

Name: 2,2′-Azobis(2-methylpropionamidine) dihydrochloride
Brand: ALDRICH

powder or granules, 97%

Synonym(s):

α,α′-Azodiisobutyramidine dihydrochloride, AAPH

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About This Item

Linear Formula:

[=NC(CH₃)₂C(=NH)NH₂]₂·2HCl

CAS Number:

2997-92-4

Molecular Weight:

271.19

Beilstein:

3718854

EC Number:

221-070-0

MDL number:

MFCD00142725

UNSPSC Code:

12162002

PubChem Substance ID:

24867630

NACRES:

NA.23

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Quality Level

200

Assay

97%

form

powder or granules

t_1/2

10 hr(56 °C)

mp

175-177 °C (lit.)

solubility

acetone, dioxane, methanol, ethanol, DMSO and water: soluble

SMILES string

Cl.Cl.CC(C)(\N=N\C(C)(C)C(N)=N)C(N)=N

InChI

1S/C8H18N6.2ClH/c1-7(2,5(9)10)13-14-8(3,4)6(11)12;;/h1-4H3,(H3,9,10)(H3,11,12);2*1H/b14-13+;;

InChI key

LXEKPEMOWBOYRF-QDBORUFSSA-N

Related Categories

Biomedical Materials

Initiators

Polymerization Tools

Application

Free radical initiator.
Polymerization initiator for acrylic, vinyl and allyl monomers.

Features and Benefits

Undergoes first order decomposition to a cationic radical. Decomposes on exposure to UV. Compatible with cationic surfactants. Decomposition rate is pH dependent

Pictograms

GHS02,GHS07,GHS09

Signal Word

Danger

Hazard Statements

H251,H302,H317,H319,H410

Precautionary Statements

P235 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Self-heat. 1 - Skin Sens. 1

Storage Class Code

4.2 - Pyrophoric and self-heating hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Exogenous glutathione is essential in the testing of antioxidant capacity using radical-induced haemolysis.

Nitya Jani et al.

Journal of pharmacological and toxicological methods, 65(3), 142-146 (2012-04-18)

Radical-induced haemolysis has been employed by many investigators to determine the antioxidant capacity of novel compounds. However the free radical generator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) results in the complete depletion of intracellular reduced glutathione (GSH) in cells that can no

Nature of interactions between PEO-PPO-PEO triblock copolymers and lipid membranes: (I) effect of polymer hydrophobicity on its ability to protect liposomes from peroxidation.

Jia-Yu Wang et al.

Biomacromolecules, 13(9), 2616-2623 (2012-07-20)

PEO-PPO-PEO triblock copolymers have opposing effects on lipid membrane integrity: they can behave either as membrane sealants or as membrane permeabilizers. To gain insights into their biomembrane activities, the fundamental interactions between a series of PEO-based polymers and phospholipid vesicles

Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys, and Gly.

Olivier Mozziconacci et al.

Chemical research in toxicology, 25(9), 1842-1861 (2012-06-21)

Glutathione thiyl radicals (GS(•)) were generated in H(2)O and D(2)O by either exposure of GSH to AAPH, photoirradiation of GSH in the presence of acetone, or photoirradiation of GSSG. Detailed interpretation of the fragmentation pathways of deuterated GSH and GSH

A new oxidative stress model, 2,2-azobis(2-amidinopropane) dihydrochloride induces cardiovascular damages in chicken embryo.

Rong-Rong He et al.

PloS one, 8(3), e57732-e57732 (2013-03-08)

It is now well established that the developing embryo is very sensitive to oxidative stress, which is a contributing factor to pregnancy-related disorders. However, little is known about the effects of reactive oxygen species (ROS) on the embryonic cardiovascular system

Purification and determination of two novel antioxidant peptides from flounder fish (Paralichthys olivaceus) using digestive proteases.

Ju-Young Ko et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 52, 113-120 (2012-11-14)

We investigated the effects of bioactive-peptides from hydrolysates of flounder fish muscle (FFM) on antioxidant activity. The hydrolysates were prepared by enzymatic reactions of FFM using eight commercial proteases such as papain, pepsin, trypsin, neutrase, alcalase, kojizyme, protamex, and α-chymotrypsin.

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2,2′-Azobis(2-methylpropionamidine) dihydrochloride