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445193

2-(Trifluoromethyl)phenylboronic acid

≥95.0%

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About This Item

Linear Formula:
CF3C6H4B(OH)2
CAS Number:
1423-27-4
Molecular Weight:
189.93
NACRES:
NA.22
PubChem Substance ID:
24868165
UNSPSC Code:
12352103
MDL number:
MFCD00236059
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assay

≥95.0%

form

solid

mp

111-114 °C (lit.)

functional group

fluoro

SMILES string

OB(O)c1ccccc1C(F)(F)F

InChI

1S/C7H6BF3O2/c9-7(10,11)5-3-1-2-4-6(5)8(12)13/h1-4,12-13H

InChI key

JNSBEPKGFVENFS-UHFFFAOYSA-N

Application

2-(Trifluoromethyl)phenylboronic acid can be used as a reactant:
  • In Suzuki-coupling reactions to prepare 2-trifluoromethyl aryl or heteroaryl derivatives.
  • To synthesize 4-(2-trifluoromethyl)phenylpyrrolo[2,3-d]pyrimidine as a potential antagonist of corticotropin-releasing hormone.
  • To prepare 2-nitro-6-(trifluoromethyl)phenylboronic acid by nitration reaction.

Other Notes

Contains varying amounts of anhydride

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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