453625
Fumaric acid monoethyl ester calcium salt
98%
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About This Item
Linear Formula:
(C2H5O2CCH=CHCO2)2Ca
CAS Number:
Molecular Weight:
326.31
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
263-369-9
MDL number:
InChI key
WOONQYHBMBCNDD-SYWGCQIGSA-L
InChI
1S/2C6H8O4.Ca/c2*1-2-10-6(9)4-3-5(7)8;/h2*3-4H,2H2,1H3,(H,7,8);/q;;+2/p-2/b2*4-3+;
SMILES string
CCOC(=O)\C=C\C(=O)O[Ca]OC(=O)\C=C\C(=O)OCC
assay
98%
mp
285 °C (dec.) (lit.)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 1
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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U Mrowietz et al.
The British journal of dermatology, 138(3), 456-460 (1998-05-15)
Systemic treatment of psoriasis with fumaric acid esters (FAE) has been found effective by empirical means. In recent years clinical studies have confirmed the antipsoriatic activity of a defined mixture of different FAE. The aim of the present prospective multicentre
M Vandermeeren et al.
Biochemical and biophysical research communications, 234(1), 19-23 (1997-05-08)
Most studies on the antipsoriatic mode of action of dimethylfumarate focused on its antiproliferative effects in keratinocytes. Because inflammatory skin diseases are associated with an upregulation of endothelial cell adhesion molecules and because the presence of inflammatory cells in dermis
Dirk W Grijpma et al.
Biomaterials, 26(16), 2795-2802 (2004-12-18)
Biodegradable polymer networks were prepared from fumaric acid derivatives of oligomeric esters. Photo-crosslinkable macromers were prepared by reacting star-shaped hydroxyl-group terminated lactide, epsilon-caprolactone and trimethylene carbonate based oligomers and fumaric acid monoethyl ester in the presence of N,N-dicyclohexylcarbodiimide and 4-dimethylamino
[Therapy of psoriasis with fumaderm preparation].
A Zesch
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 46(12), 875-876 (1995-12-01)
B Sebök et al.
European journal of pharmacology, 270(1), 79-87 (1994-01-03)
Oral administration with complex mixtures of fumaric acid derivatives is known to have antipsoriatic efficacy. The present studies aimed to clarify the mode of action and toxicity of the individual compounds. Hyperproliferative HaCaT keratinocytes in monolayer cultures were exposed to
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