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456136

(R)-(+)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane

Name: (<I>R</I>)-(+)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane
Brand: ALDRICH

98%

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₁ClO₂

CAS Number:

57044-24-3

Molecular Weight:

150.60

NACRES:

NA.22

PubChem Substance ID:

24869114

UNSPSC Code:

12352005

MDL number:

MFCD00273371

Assay:

98%

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Properties

assay

98%

optical activity

[α]24/D +42.1°, neat

refractive index

n20/D 1.434 (lit.)

bp

63 °C/37 mmHg (lit.)

density

1.103 g/mL at 25 °C (lit.)

SMILES string

CC1(C)OC[C@H](CCl)O1

InChI

1S/C6H11ClO2/c1-6(2)8-4-5(3-7)9-6/h5H,3-4H2,1-2H3/t5-/m0/s1

InChI key

BNPOTXLWPZOESZ-YFKPBYRVSA-N

Description

Application

Utilized in the preparation of both enantiomers of the orally active antifungal azolic agent ketoconazole.

pictograms

GHS02,GHS05

signalword

Danger

hcodes

H226,H318

pcodes

P210 - P233 - P240 - P241 - P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

123.8 °F - closed cup

flash_point_c

51 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Enantioselective, palladium-catalyzed alpha-arylation of N-Boc-pyrrolidine.

Kevin R Campos et al.

Journal of the American Chemical Society, 128(11), 3538-3539 (2006-03-16)

This communication discloses the first instance of the enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine. The methodology relies on Beak's sparteine-mediated, enantioselective deprotonation of N-Boc-pyrrolidine to form the 2-pyrrolidinolithium specices in high enantiomeric ratio (er). Transmetalation of this intermediate with zinc chloride

Global Trade Item Number

SKU	GTIN
456136-5G	04061837394898