459127
2-(Trifluoromethyl)phenylhydrazine
97%
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About This Item
Linear Formula:
CF3C6H4NHNH2
CAS Number:
Molecular Weight:
176.14
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
assay
97%
mp
56-60 °C (lit.)
SMILES string
NNc1ccccc1C(F)(F)F
InChI
1S/C7H7F3N2/c8-7(9,10)5-3-1-2-4-6(5)12-11/h1-4,12H,11H2
InChI key
JSWQDLBFVSTSIW-UHFFFAOYSA-N
Application
A useful intermediate employed in the preparation of biologically active azoles and aminoguanidine derivatives.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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W T Ashton et al.
Journal of medicinal chemistry, 36(23), 3595-3605 (1993-11-12)
Two series of potential angiotensin II antagonists derived from carboxyl-functionalized "diazole" heterocycles have been prepared and evaluated. Initially, a limited investigation of 4-arylimidazole-5-carboxylates led to 2-n-butyl-4-(2-chlorophenyl)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-y l] methyl]-1H-imidazole-5-carboxylic acid (12b), which was found to be a highly potent antagonist of
W T Ashton et al.
Journal of medicinal chemistry, 37(17), 2808-2824 (1994-08-19)
Several series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones with acidic sulfonamide replacements of tetrazole at the 2'-position of the biphenyl-4-ylmethyl side chain at N4 were prepared and tested as angiotensin II (AII) antagonists. Preferred substituents on the triazolinone ring were n-butyl at C5 and
Reactivity of (E)-4-Hydroxy-2-nonenal with Fluorinated Phenylhydrazines: Towards the Efficient Derivatization of an Elusive Key Biomarker of Lipid Peroxidation.
Matera R, et al.
European Journal of Organic Chemistry, 20, 3841-3851 (2012)