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Merck
CN

460559

Serotonin hydrochloride

Synonym(s):

3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O · HCl
CAS Number:
153-98-0
Molecular Weight:
212.68
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
3570963
MDL number:
MFCD00012686

Key Documents

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InChI key

MDIGAZPGKJFIAH-UHFFFAOYSA-N

SMILES string

Cl[H].NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

impurities

<4% ethanol, <5% water

mp

149-154 °C (lit.)

Biochem/physiol Actions

Neurotransmitter.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H361

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
06620DH
19018LE
02411DE
13106BE
05112MI

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Sattar Ostadhadi et al.
Fundamental & clinical pharmacology, 29(3), 310-315 (2015-02-26)
Serotonin (5-hydroxytryptamine, 5-HT) acts as a pruritogen in humans and animals, but the mechanisms of action through that serotonin induces itch response have not been extensively discovered. In our study, we attempted to investigate the role of 5-HT3 receptors in
Anita Büttner et al.
Bioorganic & medicinal chemistry, 18(10), 3387-3402 (2010-05-12)
The discovery of new templates and their subsequent elaboration to clinically useful receptor tyrosine kinase (RTK) inhibitors continues to be an important issue. RTKs are a class of enzymes responsible for the activation of different cellular signal transduction cascades. The
Steven Tran et al.
Psychopharmacology, 232(20), 3709-3718 (2015-07-27)
The zebrafish has become an increasingly popular animal model for investigating ethanol's actions in the brain and its effects on behavior. Acute exposure to ethanol in zebrafish has been shown to induce a dose-dependent increase of locomotor activity, to reduce
Magdalena Jastrzębska-Więsek et al.
Neuropharmacology, 85, 253-262 (2014-06-07)
The 5-HT6 is one of the most recent additions to the 5-HT receptor family. Its pharmacological profile and anatomical distribution is suggestive of a putative role in mood disorders. Most of preclinical evidence suggests an anxiolytic-like action of 5-HT6 receptor
S Ostadhadi et al.
Clinical and experimental dermatology, 40(6), 647-652 (2015-02-24)
Serotonin is a pruritogenic substance in humans and animals, but the mechanisms of action through which serotonin induces itch response are not yet understood. To examine the possible role of nitric oxide (NO) in the profile of scratching behaviour due
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