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Merck
CN

462047

Sigma-Aldrich

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride

97%

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About This Item

Linear Formula:
(CH3)2C6H3OCH2CH(CH3)NH2·HCl
CAS Number:
5370-01-4
Molecular Weight:
215.72
EC Number:
250-825-7
MDL number:
MFCD00216024
UNSPSC Code:
12352100
PubChem Substance ID:
24869930
NACRES:
NA.22

Key Documents

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Assay

97%

form

solid

mp

200-203 °C (lit.)

SMILES string

Cl.CC(N)COc1c(C)cccc1C

InChI

1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H

InChI key

NFEIBWMZVIVJLQ-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

General description

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (Mexiletine) is an anti-arrhythmic agent having local anaesthetic activity. Mexiletine belongs to the triclinc crystal system, with the asymmetric unit containing two independent molecules.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
09708AR

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Sivy J, et al.
Acta Crystallographica Section C, Structural Chemistry, 47(12), 2695-2695 (1991)
Drug-induced hypersensitivity syndrome complicated with concurrent fulminant type 1 diabetes mellitus and Hashimoto's thyroiditis.
Yusuke Minegaki et al.
International journal of dermatology, 52(3), 355-357 (2013-02-19)
Alessia Catalano et al.
Journal of medicinal chemistry, 55(3), 1418-1422 (2011-12-24)
The first synthesis of m-hydroxymexiletine (MHM) has been accomplished. MHM displayed hNav1.5 sodium channel blocking activity, and tests indicate it to be ∼2-fold more potent than the parent mexiletine and to have more favorable toxicological properties than mexiletine. Thus, MHM
Andrias O O'Reilly et al.
PloS one, 7(7), e41667-e41667 (2012-08-01)
Bisphenol A (BPA) has attracted considerable public attention as it leaches from plastic used in food containers, is detectable in human fluids and recent epidemiologic studies link BPA exposure with diseases including cardiovascular disorders. As heart-toxicity may derive from modified
Alessia Catalano et al.
Drug metabolism letters, 6(2), 124-128 (2012-08-02)
m-Hydroxymexiletine (MHM), a minor metabolite of the class IB anti-arrhythmic drug mexiletine, is about two fold more potent than the parent compound on human cardiac voltage-gated sodium channels (hNav1.5), and equipotent to mexiletine on human skeletal-muscle voltage-gated sodium channels (hNav1.4).
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