462047
1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride
97%
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About This Item
Linear Formula:
(CH3)2C6H3OCH2CH(CH3)NH2·HCl
CAS Number:
Molecular Weight:
215.72
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
250-825-7
MDL number:
Assay:
97%
Form:
solid
InChI key
NFEIBWMZVIVJLQ-UHFFFAOYSA-N
InChI
1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
SMILES string
Cl.CC(N)COc1c(C)cccc1C
assay
97%
form
solid
mp
200-203 °C (lit.)
Gene Information
General description
1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (Mexiletine) is an anti-arrhythmic agent having local anaesthetic activity. Mexiletine belongs to the triclinc crystal system, with the asymmetric unit containing two independent molecules.
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Jeffrey M Statland et al.
JAMA, 308(13), 1357-1365 (2012-10-04)
Nondystrophic myotonias (NDMs) are rare diseases caused by mutations in skeletal muscle ion channels. Patients experience delayed muscle relaxation causing functionally limiting stiffness and pain. Mexiletine-induced sodium channel blockade reduced myotonia in small studies; however, as is common in rare
A Jakob et al.
Klinische Padiatrie, 224(5), 309-312 (2011-12-16)
Erythromelalgia is a rare disorder characterized by recurrent pain attacks, swelling and redness in the distal extremities. The primary forms of the disorder are caused by mutations in voltage-gated sodium channels. Treatment is difficult and controlled therapeutic studies offer little
Michela De Bellis et al.
Biophysical journal, 104(2), 344-354 (2013-02-28)
Previously identified potent and/or use-dependent mexiletine (Mex) analogs were used as template for the rational design of new Na(v)-channel blockers. The effects of the novel analogs were tested on sodium currents of native myofibers. Data and molecular modeling show that
Sivy J, et al.
Acta Crystallographica Section C, Structural Chemistry, 47(12), 2695-2695 (1991)
Lushan Yu et al.
The Journal of pharmacy and pharmacology, 64(6), 792-801 (2012-05-11)
This study examined the interaction of mexiletine enantiomers with human plasma, human serum albumin (HSA), and human α1-acid glycoprotein (hAGP), and characterized the binding modes of mexiletine enantiomers with hAGP in the molecular level. Enantiomer separation of mexiletine was performed
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