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Merck
CN

463442

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide

95%

Synonym(s):

4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide

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About This Item

Linear Formula:
ClC6H3(OCH3)CONHCH2C6H4SO2NH2
CAS Number:
16673-34-0
Molecular Weight:
368.84
NACRES:
NA.22
PubChem Substance ID:
24870067
UNSPSC Code:
12352100
EC Number:
240-722-5
MDL number:
MFCD00193756

Key Documents

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Product Name

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide, 95%

InChI key

KVWWTCSJLGHLRM-UHFFFAOYSA-N

InChI

1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)

SMILES string

COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(N)(=O)=O

assay

95%

mp

209-214 °C (lit.)

functional group

amide
chloro

Quality Level

100

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General description

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
18530LQ

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Molecular regulation of cell fate in cerebral ischemia: role of the inflammasome and connected pathways
Trendelenburg G.
Journal of Cerebral Blood Flow and Metabolism (2014)
Carlo Marchetti et al.
Journal of cardiovascular pharmacology, 63(4), 316-322 (2013-12-18)
The formation of the NLRP3 inflammasome in the heart during acute myocardial infarction amplifies the inflammatory response and mediates further damage. Glyburide has NLRP3 inhibitory activity in vitro but requires very high doses in vivo, associated with hypoglycemia. The aim
Reply to Letter Regarding Article," NLRP3 Inflammasome as a Therapeutic Target in Myocardial Infarction.
Takahashi M.
International Heart Journal, 55(4), 380-380 (2014)

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