469009
2-Nitrophenyl phenyl sulfone
97%
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About This Item
Linear Formula:
O2NC6H4SO2C6H5
CAS Number:
Molecular Weight:
263.27
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
250-672-6
MDL number:
assay
97%
mp
145-148 °C (lit.)
SMILES string
[O-][N+](=O)c1ccccc1S(=O)(=O)c2ccccc2
InChI
1S/C12H9NO4S/c14-13(15)11-8-4-5-9-12(11)18(16,17)10-6-2-1-3-7-10/h1-9H
InChI key
GKNMUCPEXSCGKC-UHFFFAOYSA-N
General description
2-Nitrophenyl phenyl sulfone (NPPS) is a substituted diarylsulfone derivative. It has been reported to protect the human CEM-SS lymphoblastoid cells from the cytopathic effects of HIV-1 in cell culture. Structure-activity relationship of 2-nitrophenyl phenyl sulfone has been studied.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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M Artico et al.
Archiv der Pharmazie, 328(3), 223-229 (1995-03-01)
Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41
J B McMahon et al.
Antimicrobial agents and chemotherapy, 37(4), 754-760 (1993-04-01)
A series of variously substituted diarylsulfones and related derivatives were found to prevent human immunodeficiency virus type 1 (HIV-1) replication and HIV-1-induced cell killing in vitro. One of the more potent derivatives, 2-nitrophenyl phenyl sulfone (NPPS), completely protected human CEM-SS
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