469599
Ethyl chlorodifluoroacetate
98%
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Linear Formula:
ClCF2CO2C2H5
CAS Number:
Molecular Weight:
158.53
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
206-850-0
MDL number:
Assay:
98%
Quality Level
assay
98%
refractive index
n20/D 1.358 (lit.)
bp
96-97.5 °C (lit.)
density
1.252 g/mL at 25 °C (lit.)
functional group
chloro, ester, fluoro
SMILES string
CCOC(=O)C(F)(F)Cl
InChI
1S/C4H5ClF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
InChI key
GVCAWQUJCHZRCB-UHFFFAOYSA-N
General description
Ethyl chlorodifluoroacetate (ECDFA) undergoes Reformatskii reaction with various aldehydes in DMF. It reacts with phenylacetylene to afford ethyl α,α−difluoro-4-phenyl-3-butenoates.
Application
Ethyl chlorodifluoroacetate (ECDFA) may be used as a starting reagent in the synthesis of 3-gem-difluoro-2-ethoxy allylic alcohols.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
64.4 °F - closed cup
flash_point_c
18 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
危险化学品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
A theoretical investigation on the kinetics and reactivity of the gas-phase reactions of ethyl chlorodifluoroacetate with OH radical and Cl atom at 298 K.
Mishra BK, et al.
Structural Chemistry, 25(2), 463-470 (2014)
Fluorine-containing organozinc reagents. IV.: Reformatskii-type reactions of chlorodifluoroacet1c acid derivatives.
Lang RW and Schaub B.
Tetrahedron Letters, 29(24), 2943-2946 (1988)
Synthesis of 3-gem-difluoro-2-ethoxy allylic alcohols from ethyl chlorodifluoroacetate.
Begue J-P, et al.
Tetrahedron Letters, 35(3), 6097-6100 (1994)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 469599-25ML | 04061836692483 |