470007
D-Histidinol dihydrochloride
98%
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About This Item
Empirical Formula (Hill Notation):
C6H11N3O · 2HCl
CAS Number:
Molecular Weight:
214.09
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.22
Assay
98%
optical activity
[α]20/D +3°, c = 1 in H2O
reaction suitability
reaction type: solution phase peptide synthesis
mp
193-195 °C (lit.)
application(s)
peptide synthesis
SMILES string
Cl.Cl.N[C@@H](CO)Cc1c[nH]cn1
InChI
1S/C6H11N3O.2ClH/c7-5(3-10)1-6-2-8-4-9-6;;/h2,4-5,10H,1,3,7H2,(H,8,9);2*1H/t5-;;/m1../s1
InChI key
FRCAFNBBXRWXQA-ZJIMSODOSA-N
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Zhihong Zeng et al.
The Journal of biological chemistry, 286(1), 403-409 (2010-10-30)
Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5'-phosphotyrosyl bond. Although these intermediates are normally transient, they can be stabilized by antitumor agents that act as Top2
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