47296
o-Fluoro-L-phenylalanine
puriss., ≥99.0% (sum of enantiomers, HPLC)
Synonym(s):
2-Fluoro-L-phenylalanine
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About This Item
Empirical Formula (Hill Notation):
C9H10FNO2
CAS Number:
Molecular Weight:
183.18
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
2805791
grade
puriss.
assay
≥99.0% (sum of enantiomers, HPLC)
optical activity
[α]20/D −14±1°, c = 1% in H2O
optical purity
enantiomeric ratio: ≥99.5:0.5 (TLC)
SMILES string
N[C@@H](Cc1ccccc1F)C(O)=O
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Johnny Castillo Meleán et al.
Organic & biomolecular chemistry, 9(3), 765-769 (2010-11-23)
2-[(18)F]Fluoro-L-phenylalanine and 2-[(18)F]fluoro-L-tyrosine have been developed as promising radiopharmaceuticals for molecular imaging using positron emission tomography (PET). However, the lack of a convenient radiosynthetic pathway has limited their practical use. In this work a new three-step nucleophilic synthesis of these
K Kubota et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 37(2), 320-325 (1996-02-01)
L-[methyl-11C]methionine (11C-Met) is a useful tracer for tumor imaging with PET. The drawbacks include a short half-life and high physiological accumulation in abdominal organs. To overcome these shortfalls, the feasible use of [18F]fluorophenylalanine (18F-Phe), which shares the same amino acid
Kensuke Okuda et al.
Biochemistry, 44(17), 6675-6684 (2005-04-27)
The ribosome-catalyzed peptidyl transferase reaction displays a complex pH profile resulting from two functional groups whose deprotonation is important for the reaction, one within the A-site substrate and a second unidentified group thought to reside in the rRNA peptidyl transferase