47437
Fmoc-D-Tic-OH
≥98.0% (TLC)
Synonym(s):
(R)-N-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C25H21NO4
CAS Number:
Molecular Weight:
399.44
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
7499344
MDL number:
assay
≥98.0% (TLC)
optical activity
[α]20/D −25.0±2°, c = 0.6% in methanol
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
SMILES string
OC(=O)[C@H]1Cc2ccccc2CN1C(=O)OCC3c4ccccc4-c5ccccc35
InChI
1S/C25H21NO4/c27-24(28)23-13-16-7-1-2-8-17(16)14-26(23)25(29)30-15-22-20-11-5-3-9-18(20)19-10-4-6-12-21(19)22/h1-12,22-23H,13-15H2,(H,27,28)/t23-/m1/s1
InChI key
LIRBCUNCXDZOOU-HSZRJFAPSA-N
Other Notes
FMOC-D-Tic is employed e.g. for the solid-phase synthesis of Bradykinin antagonists
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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C Thurieau et al.
Journal of medicinal chemistry, 39(10), 2095-2101 (1996-05-10)
We report here on the synthesis and pharmacological properties of a new series of small linear and cyclic peptides derived from the five C-terminal amino acid residues of second-generation bradykinin receptor antagonists. Variations of the two first residues of the
V S Goodfellow et al.
Journal of medicinal chemistry, 39(7), 1472-1484 (1996-03-29)
We report a systematic probing of the structural requirements of the bradykinin (BK) type 2 (B(2)) receptor for antagonist activity by incorporating N-alkyl-amino acid residues at positions 7 and 8 of a potent antagonist sequence. Compound 1 (D-Arg(0)-Arg(1)-Pro(2)-Hyp(3)-Gly(4)-Thi(5)-Ser(6)-D-Tic(7)-N-Chg (8)-Arg(9), CP-0597)(1,2)