476951
(2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane
99%
Synonym(s):
tert-Butyl [S-(R*,R*)]-(−)-(1-oxiranyl-2-phenylethyl)carbamate
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About This Item
Empirical Formula (Hill Notation):
C15H21NO3
CAS Number:
Molecular Weight:
263.33
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
Assay
99%
optical activity
[α]23/D −7°, c = 0.6 in methanol
mp
125-127 °C (lit.)
functional group
amine
ether
phenyl
SMILES string
[H][C@@]1(CO1)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C
InChI
1S/C15H21NO3/c1-15(2,3)19-14(17)16-12(13-10-18-13)9-11-7-5-4-6-8-11/h4-8,12-13H,9-10H2,1-3H3,(H,16,17)/t12-,13+/m0/s1
InChI key
NVPOUMXZERMIJK-QWHCGFSZSA-N
Application
(2S,3S)-1,2-Epoxy-3-(Boc-amino)-4-phenylbutane can be used as a reactant to prepare:
- Hydroxyethyl urea peptidomimetics as potent γ-secretase inhibitors.
- Arylsufonamide derivatives.
- Peptidomimetic β-secretase inhibitors incorporating hydroxyethylamine isosteres.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Akbar Ali et al.
Journal of medicinal chemistry, 49(25), 7342-7356 (2006-12-08)
Here, we describe the design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors incorporating N-phenyloxazolidinone-5-carboxamides into the (hydroxyethylamino)sulfonamide scaffold as P2 ligands. Series of inhibitors with variations at the P2 phenyloxazolidinone and the P2' phenylsulfonamide moieties were synthesized. Compounds
William P Esler et al.
Bioorganic & medicinal chemistry letters, 14(8), 1935-1938 (2004-03-31)
(Hydroxyethyl)urea peptidomimetics are potent inhibitors of gamma-secretase that are accessible in a few synthetic steps. Systematic alteration of P2-P4' revealed that the corresponding S2-S4' active site pockets accommodate a variety of substituents, consistent with the fact that this protease cleaves
Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains
Miller JF, et al.
Bioorganic & Medicinal Chemistry Letters, 14(4), 959-963 (2004)
Arun K Ghosh et al.
Journal of medicinal chemistry, 49(17), 5252-5261 (2006-08-18)
Structure-based design and synthesis of novel HIV protease inhibitors are described. The inhibitors are designed specifically to interact with the backbone of HIV protease active site to combat drug resistance. Inhibitor 3 has exhibited exceedingly potent enzyme inhibitory and antiviral
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands
Ali Akbar, et al.
Journal of medicinal chemistry, 49(25), 7342-7356 (2006)
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