Merck
CN
All Photos(2)

Documents

479306

Sigma-Aldrich

cis-Diamineplatinum(II) dichloride

≥99.9% trace metals basis

Sign Into View Organizational & Contract Pricing
All Photos(2)
Synonym(s):
cis-Diammineplatinum(II) dichloride, cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin
Linear Formula:
Pt(NH3)2Cl2
CAS Number:
15663-27-1
Molecular Weight:
300.05
EC Number:
239-733-8
MDL number:
MFCD00011623
PubChem Substance ID:
24871609
NACRES:
NA.22

Quality Level

100

Assay

≥99.9% trace metals basis

reaction suitability

core: platinum
reagent type: catalyst

mp

270 °C (lit.)

antibiotic activity spectrum

neoplastics

Mode of action

DNA synthesis | interferes

SMILES string

N.N.Cl[Pt]Cl

InChI

1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChI key

LXZZYRPGZAFOLE-UHFFFAOYSA-L

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

cis-Diamineplatinum(II) dichloride can be used as a model drug to test the efficiency of various drug carriers in drug delivery.
Highly active chemotherapeutic agent for use in preventing the advancement of testicular cancer.

Biochem/physiol Actions

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How can I get Product 479306, cis-Diammineplatinum(II) dichloride, in solution?

    cis-Diammineplatinum(II) dichloride is soluble in water at 25°C. It is also soluble in N,N-dimethylformamide (DMF), dimethylacetamide and dimethyl sulfoxide (DMSO). We do not test solution stability of this product. However, we do have stability data on a document on another cis-Diammineplatinum(II) dichloride product; the product number is P4394.

  4. How should Product 479306, cis-Diammineplatinum(II) dichloride be stored?

    This product should be stored at room temperature.

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy.
Xu P, et al.
Colloids and Surfaces. B, Biointerfaces, 48(1), 50-57 (2006)
Synthesis of a new nanoparticle system based on electrostatic alginate?piperazine interactions.
Roman JV, et al.
Polymers For Advanced Technologies, 27(5), 623-629 (2016)
Pedro J Beltran et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(11), 2947-2958 (2014-04-15)
Insulin-like growth factor 1 receptor (IGF-IR) has been implicated in the pathogenesis of ovarian cancer. Ganitumab is an investigational, fully human monoclonal antibody against IGF-IR. Here, we explore the therapeutic potential of ganitumab for the treatment of ovarian cancer. The
Koji Tanaka et al.
Carcinogenesis, 36(8), 894-903 (2015-05-31)
There is increasing evidence that the expression of microRNA (miRNA) in cancer is associated with chemosensitivity but the mechanism of miRNA-induced chemoresistance has not been fully elucidated. The aim of this study was to examine the role of extracellular miRNA
Abdullah A Osman et al.
Cancer research, 75(7), 1205-1215 (2015-02-19)
TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC), with mutations occurring in over two thirds of cases; however, the predictive response of these mutations to cisplatin-based therapy remains elusive. In the current study
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service