479977
2-Hydroxy-5-nitrobenzyl alcohol
98%
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About This Item
Linear Formula:
HOC6H3(NO2)CH2OH
CAS Number:
Molecular Weight:
169.13
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Product Name
2-Hydroxy-5-nitrobenzyl alcohol, 98%
InChI
1S/C7H7NO4/c9-4-5-3-6(8(11)12)1-2-7(5)10/h1-3,9-10H,4H2
SMILES string
OCc1cc(ccc1O)[N+]([O-])=O
InChI key
JEIYIXDNZKATLC-UHFFFAOYSA-N
assay
98%
mp
123-127 °C (lit.)
functional group
hydroxyl
nitro
General description
2-Hydroxy-5-nitrobenzyl alcohol (HNB) can be synthesized from dimethyl(2-hydroxyl-5-nitrobenzyl)sulfonium bromide. Its crystal structure has been analyzed. The interaction of HNB with glutathione S-transferases (GSTs) at tryptophan residues has been investigated.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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2-Hydroxy-5-nitrobenzyl alcohol.
Lei G, et al.
Acta Crystallographica Section E, Structure Reports Online, 62(10), o4224-o4225 (2006)
Inês F Antunes et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(3), 451-458 (2012-02-11)
Activation of microglia is a hallmark of inflammatory, infectious, and degenerative diseases of the central nervous system. Several studies have indicated that there is an increase in release of β-glucuronidase by activated microglia into the extracellular space at the site
R M McCarthy et al.
Biochimica et biophysica acta, 1293(2), 185-190 (1996-04-16)
2-Hydroxy-5-nitrobenzyl alcohol (HNB) was prepared from dimethyl(2-hydroxyl-5-nitrobenzyl)sulfonium bromide (HNBB). HNB binds to glutathione S-transferases (GSTs) 1-2 and 2-2 with moderate affinity at a site separate from 1-anilino-8-naphthalenesulfonate (ANS). Intrinsic fluorescence due to Trp-21 is strongly quenched by HNB binding but
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