480959
Glycolamide
98%
Synonym(s):
2-Hydroxyacetamide
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About This Item
Linear Formula:
HOCH2CONH2
CAS Number:
Molecular Weight:
75.07
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
98%
InChI
1S/C2H5NO2/c3-2(5)1-4/h4H,1H2,(H2,3,5)
SMILES string
NC(=O)CO
InChI key
TZGPACAKMCUCKX-UHFFFAOYSA-N
assay
98%
mp
118-120 °C (lit.)
functional group
amide, hydroxyl
Quality Level
Related Categories
General description
Glycolamide, an isomer of glycine, can be synthesized by the ammonolysis of ethyl glycolate. The conformational analysis of glycolamide has been reported. Its diffusion coefficient in water and partial molal isothermal compressibility has been determined. Its thermodynamic properties have been investigated. Its osmotic and activity coefficients have been obtained.
Application
Glycolamide may be used in the preparation of phosphoglycolamide.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Parmeshwari K Halen et al.
Mini reviews in medicinal chemistry, 9(1), 124-139 (2009-01-20)
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome
Partial molal isothermal compressibility of glycine, DL-α-alanine, glycylglycine, glycolamide, and lactamide.
Yayanos AA.
The Journal of Physical Chemistry, 97(49), 13027-13028 (1993)
Fereidoon Daryaee et al.
European journal of medicinal chemistry, 44(1), 289-295 (2008-04-26)
On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide 1 (2,2-dimethyl-5-oxo-1,3-dioxolane)
P R Brown et al.
Journal of general microbiology, 133(6), 1527-1533 (1987-06-01)
A positive selection is described for isolating amidase-negative mutants from Pseudomonas aeruginosa strains. The method is based on the conversion, via amidase activity, of glycollamide to glycollate which is growth inhibitory. Three types of mutant were isolated on lactate medium
A K Bansal et al.
Drug development and industrial pharmacy, 27(1), 63-70 (2001-03-15)
Glycolamide esters of ibuprofen (I), namely, unsubstituted (II), N,N dimethyl (III), and N,N diethyl (IV), were synthesized and studied for different physicochemical, pharmacological, and toxicological properties. They were comparable with I in respect of anti-inflammatory and analgesic activity but did
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