Key Documents

View All Documentation

482641

(S)-(+)-2-Fluoro-α-methyl-4-biphenylacetic acid

Name: (<I>S</I>)-(+)-2-Fluoro-α-methyl-4-biphenylacetic acid
Brand: ALDRICH

98%

Synonym(s):

(S)-(+)-Flurbiprofen

Select a Size

Change View

About This Item

Linear Formula:

C₆H₅C₆H₃(F)CH(CH₃)CO₂H

CAS Number:

51543-39-6

Molecular Weight:

244.26

UNSPSC Code:

12352000

PubChem Substance ID:

24871839

EC Number:

257-263-1

MDL number:

MFCD00866152

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

assay

98%

optical activity

[α]24/D +43°, c = 1 in chloroform

mp

109-110 °C (lit.)

SMILES string

C[C@H](C(O)=O)c1ccc(c(F)c1)-c2ccccc2

Gene Information

human ... IL8RA(3577)

Description

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.

Ilaria Peretto et al.

Journal of medicinal chemistry, 48(18), 5705-5720 (2005-09-02)

Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been recently described to selectively inhibit beta-amyloid(1)(-)(42) (Abeta42) secretion, the most toxic component of the senile plaques present in the brain of Alzheimer patients. The use of this NSAID in Alzheimer's disease (AD)

2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.

Marcello Allegretti et al.

Journal of medicinal chemistry, 48(13), 4312-4331 (2005-06-25)

The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2

The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.

Nicholas Stock et al.

Bioorganic & medicinal chemistry letters, 16(8), 2219-2223 (2006-02-04)

The subtle modification of a selection of Abeta42 inhibiting non-steroidal anti-inflammatory drugs (NSAIDs), through synthesis of the geminal dimethyl analogues, was anticipated to ablate their cyclooxygenase activity whilst maintaining Abeta42 inhibition. Methylflurbiprofen 6 exhibited similar in vitro Abeta42 inhibition to

View All Related Papers