494364
2-Amino-3,5-dibromopyrazine
97%
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About This Item
Empirical Formula (Hill Notation):
C4H3Br2N3
CAS Number:
Molecular Weight:
252.89
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
Assay:
97%
assay
97%
mp
114-117 °C (lit.)
functional group
bromo
SMILES string
Nc1ncc(Br)nc1Br
InChI
1S/C4H3Br2N3/c5-2-1-8-4(7)3(6)9-2/h1H,(H2,7,8)
InChI key
DTLBKXRFWUERQN-UHFFFAOYSA-N
General description
2-Amino-3,5-dibromopyrazine can be synthesized from 2-aminopyrazine via bromination using N-bromosuccinimide (NBS). It reacts with sodium dicyanocuprate to form a mixture of mono and dicyanation products. The formation of 2-aminothiazolopyrazines by reacting 2-amino-3,5-dibromopyrazine with isothiocyanates has been reported.
Application
2-Amino-3,5-dibromopyrazine may be used in the synthesis of:
- 2-amino-5-bromopyrazin-3-thiol
- 2-amino-3,5-bis(p-methoxyphenyl)-1,4-pyrazine
- 3,7-dihydroimidazo[1,2a]pyrazine-3-ones
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Regulatory Information
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Studies on pyrazines. XX, A simple synthesis of 5-substituted 2-amino-3-cyanopyrazines: useful intermediates for pteridine synthesis.
Synthesis 8 (1990): 659-660.
Synthesis 8 (1990): 659-660.
Sato N and Takeuchi R.
Synthesis, 8, 659-660 (1990)
Synthesis of N-Substituted-2-Aminothiazolo [4,5-b] pyrazines by Tandem Reaction of o-Aminohalopyrazines with Isothiocyanates.
Kwak SH, et al.
Bull. Korean Chem. Soc., 33, 4271-4274 (2012)
Synthesis of Tetraaza Derivatives of Benzoxazinophenothiazine.
Ezema BE, et al.
Orient. J. Chem., 31(1), 133-139 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 494364-1G | 04061825754383 |