499137
Sodium 4-methyl-2-oxovalerate
98%
Synonym(s):
α-Ketoisocaproic acid sodium salt, 4-Methyl-2-oxopentanoic acid sodium salt, 4-Methyl-2-oxovaleric acid sodium salt, Ketoleucine sodium salt
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About This Item
Linear Formula:
(CH3)2CHCH2COCOONa
CAS Number:
Molecular Weight:
152.12
EC Number:
224-816-3
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
4239297
InChI
1S/C6H10O3.Na/c1-4(2)3-5(7)6(8)9;/h4H,3H2,1-2H3,(H,8,9);/q;+1/p-1
InChI key
IXFAZKRLPPMQEO-UHFFFAOYSA-M
SMILES string
[Na+].CC(C)CC(=O)C([O-])=O
assay
98%
mp
275 °C (dec.) (lit.)
Application
Condensation with α-amino ketones and subsequent cyclization provides pyrazinones.
wgk
WGK 3
Storage Class
11 - Combustible Solids
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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D A Roberts et al.
Journal of medicinal chemistry, 33(9), 2326-2334 (1990-09-01)
A series of 1,2,4-triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity, which incorporate (1S,2S)-2-amino-1,3-dicyclohexyl-1-hydroxypropane, statine (Sta), and (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy-pentanoic acid (ACHPA) transition-state mimetics, have been prepared. Structure-activity relationships for renin inhibitory activity in the series are consistent with the 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(3 pyridyl)propionic acid
Heterocycles, 31, 1647-1647 (1990)
Rajavel Elango et al.
The American journal of clinical nutrition, 96(4), 759-767 (2012-09-07)
Leucine has been suggested to improve athletic performance. Therefore, the branched-chain amino acids (BCAAs), especially leucine, are popular as dietary supplements in strength-training athletes; however, the intake of leucine in excess of requirements raises concerns regarding adverse effects. Currently, the
Hui You et al.
American journal of physiology. Endocrinology and metabolism, 300(3), E435-E444 (2010-10-21)
Atrial natriuretic peptide (ANP) levels correlate with hyperglycemia in diabetes mellitus, but ANP effects on pancreatic islet β-cell insulin secretion are controversial. ANP was investigated for short- and long-term effects on insulin secretion and mechanisms regulating secretion in isolated rat
M Willenborg et al.
Biochemical pharmacology, 80(1), 104-112 (2010-03-23)
The K(+) channel blocker, TEA is known to increase action potential amplitude and insulin secretion of mouse beta-cells when added to a nutrient secretagogue. In the presence of a maximally effective sulfonylurea concentration (2.7 microM glipizide) the nutrient secretagogue alpha-ketoisocaproic
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