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512443

3-Chloro-L-tyrosine

Name: 3-Chloro-<SC>L</SC>-tyrosine
Brand: ALDRICH

97%

Synonym(s):

(2S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid, Monochlorotyrosine

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About This Item

Linear Formula:

4-(HO)C₆H₃(Cl)CH₂CH(NH₂)CO₂H

CAS Number:

7423-93-0

Molecular Weight:

215.63

PubChem Substance ID:

24873634

eCl@ss:

32160406

UNSPSC Code:

12352209

NACRES:

NA.22

EC Number:

231-050-3

MDL number:

MFCD00045865

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Properties

Quality Level

100

assay

97%

optical activity

[α]24/D −2°, c = 1 in 1 M HCl

reaction suitability

reaction type: solution phase peptide synthesis

mp

249 °C (lit.)

application(s)

peptide synthesis

SMILES string

N[C@@H](Cc1ccc(O)c(Cl)c1)C(O)=O

InChI

1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

InChI key

ACWBBAGYTKWBCD-ZETCQYMHSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Protein carbamylation renders high-density lipoprotein dysfunctional.

Michael Holzer et al.

Antioxidants & redox signaling, 14(12), 2337-2346 (2011-01-18)

Carbamylation of proteins through reactive cyanate has been demonstrated to predict an increased cardiovascular risk. Cyanate is formed in vivo by breakdown of urea and at sites of inflammation by the phagocyte protein myeloperoxidase. Because myeloperoxidase (MPO) associates with high-density

Kinetics of 3-chlorotyrosine formation and loss due to hypochlorous acid and chloramines.

Matthew P Curtis et al.

Chemical research in toxicology, 24(3), 418-428 (2011-02-16)

The persistent activation of innate immune cells in chronic inflammation is gaining recognition as a contributing factor in a number of human diseases. A distinguishing feature of activated leukocytes at sites of inflammation is their production of reactive species such

Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period.

Mariusz G Fleszar et al.

Molecules (Basel, Switzerland), 25(21) (2020-11-11)

Quantification with satisfactory specificity and sensitivity of free 3-Nitro-l-tyrosine (3-NT), 3-Chloro-l-tyrosine (3-CT), and 3-Bromo-l-tyrosine (3-BT) in biological samples as potential inflammation, oxidative stress, and cancer biomarkers is analytically challenging. We aimed at developing a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method

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Global Trade Item Number

SKU	GTIN
512443-1G	04061826102268