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Merck
CN

512443

3-Chloro-L-tyrosine

97%

Synonym(s):

(2S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid, Monochlorotyrosine

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About This Item

Linear Formula:
4-(HO)C6H3(Cl)CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
215.63
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
NACRES:
NA.22
EC Number:
231-050-3
MDL number:
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InChI key

ACWBBAGYTKWBCD-ZETCQYMHSA-N

InChI

1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

SMILES string

N[C@@H](Cc1ccc(O)c(Cl)c1)C(O)=O

assay

97%

optical activity

[α]24/D −2°, c = 1 in 1 M HCl

reaction suitability

reaction type: solution phase peptide synthesis

mp

249 °C (lit.)

application(s)

peptide synthesis

Quality Level

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Michael Holzer et al.
Antioxidants & redox signaling, 14(12), 2337-2346 (2011-01-18)
Carbamylation of proteins through reactive cyanate has been demonstrated to predict an increased cardiovascular risk. Cyanate is formed in vivo by breakdown of urea and at sites of inflammation by the phagocyte protein myeloperoxidase. Because myeloperoxidase (MPO) associates with high-density
Matthew P Curtis et al.
Chemical research in toxicology, 24(3), 418-428 (2011-02-16)
The persistent activation of innate immune cells in chronic inflammation is gaining recognition as a contributing factor in a number of human diseases. A distinguishing feature of activated leukocytes at sites of inflammation is their production of reactive species such
Mariusz G Fleszar et al.
Molecules (Basel, Switzerland), 25(21) (2020-11-11)
Quantification with satisfactory specificity and sensitivity of free 3-Nitro-l-tyrosine (3-NT), 3-Chloro-l-tyrosine (3-CT), and 3-Bromo-l-tyrosine (3-BT) in biological samples as potential inflammation, oxidative stress, and cancer biomarkers is analytically challenging. We aimed at developing a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method
Cédric Delporte et al.
Talanta, 99, 603-609 (2012-09-13)
A high degree of uremia is common in patients with end-stage renal disease and has been linked to the development of chronic inflammation and cardiovascular diseases. In conditions where transplantation is not possible, uremia can be reduced by hemodialysis although
Joseph I Kang et al.
Chemical research in toxicology, 21(5), 1028-1038 (2008-05-03)
While the last 30 years chronicles an extensive effort to understand the damage to DNA caused by reactive oxygen species (ROS), little research has examined the chemical damage to the histone proteins found in chromatin. Hypochlorous acid (HOCl), the primary

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