512443
3-Chloro-L-tyrosine
97%
Synonym(s):
(2S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid, Monochlorotyrosine
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About This Item
Linear Formula:
4-(HO)C6H3(Cl)CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
215.63
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
NACRES:
NA.22
EC Number:
231-050-3
MDL number:
InChI key
ACWBBAGYTKWBCD-ZETCQYMHSA-N
InChI
1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
SMILES string
N[C@@H](Cc1ccc(O)c(Cl)c1)C(O)=O
assay
97%
optical activity
[α]24/D −2°, c = 1 in 1 M HCl
reaction suitability
reaction type: solution phase peptide synthesis
mp
249 °C (lit.)
application(s)
peptide synthesis
Quality Level
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Eline Thomson et al.
Free radical biology & medicine, 49(9), 1354-1360 (2010-07-22)
We aimed to determine whether myeloperoxidase (MPO) is the main peroxidase present in the airways of children with cystic fibrosis (CF) and to assess which oxidants it produces and whether they are associated with clinical features of CF. Children with
Laetitia Mouls et al.
Proteomics, 9(6), 1617-1631 (2009-03-03)
Protein oxidation is thought to contribute to a number of inflammatory diseases, hence the development of sensitive and specific analytical techniques to detect oxidative PTMs (oxPTMs) in biological samples is highly desirable. Precursor ion scanning for fragment ions of oxidized
Jihan Talib et al.
Free radical biology & medicine, 53(1), 20-29 (2012-05-23)
Smokers have an elevated risk of atherosclerosis but the origin of this elevated risk is incompletely defined, though increasing evidence supports a role for the oxidant-generating enzyme myeloperoxidase (MPO). In previous studies we have demonstrated that smokers have elevated levels
Michael Holzer et al.
Antioxidants & redox signaling, 14(12), 2337-2346 (2011-01-18)
Carbamylation of proteins through reactive cyanate has been demonstrated to predict an increased cardiovascular risk. Cyanate is formed in vivo by breakdown of urea and at sites of inflammation by the phagocyte protein myeloperoxidase. Because myeloperoxidase (MPO) associates with high-density
Matthew P Curtis et al.
Chemical research in toxicology, 24(3), 418-428 (2011-02-16)
The persistent activation of innate immune cells in chronic inflammation is gaining recognition as a contributing factor in a number of human diseases. A distinguishing feature of activated leukocytes at sites of inflammation is their production of reactive species such
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