513067
2-Hydroxychalcone
95%
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About This Item
Linear Formula:
HOC6H4CH=CHCOC6H5
CAS Number:
Molecular Weight:
224.25
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
assay
95%
mp
144-150 °C (lit.)
SMILES string
Oc1ccccc1\C=C\C(=O)c2ccccc2
InChI
1S/C15H12O2/c16-14-9-5-4-8-13(14)10-11-15(17)12-6-2-1-3-7-12/h1-11,16H/b11-10+
InChI key
UDOOPSJCRMKSGL-ZHACJKMWSA-N
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Kunan Bangphumi et al.
European journal of drug metabolism and pharmacokinetics, 41(6), 777-785 (2015-11-14)
Curcumin is the major bioactive component of turmeric, but has poor oral bioavailability that limits its clinical applications. To improve the in vitro solubility and alkaline stability, we developed a prodrug of curcumin by succinylation to obtain curcumin diethyl disuccinate
Jie Li et al.
Cell discovery, 3, 17023-17023 (2017-07-13)
Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the inflammation or fibrosis molecular events in pneumoconiosis. Here, we performed
Cesar Echeverria et al.
International journal of molecular sciences, 10(1), 221-231 (2009-04-01)
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the