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518654

4-Amino-2-chloro-6,7-dimethoxyquinazoline

Name: 4-Amino-2-chloro-6,7-dimethoxyquinazoline
Brand: ALDRICH

95%

Synonym(s):

2-Chloro-6,7-dimethoxy-4-quinazolinamine

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₀ClN₃O₂

CAS Number:

23680-84-4

Molecular Weight:

239.66

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24874035

EC Number:

245-821-7

Beilstein/REAXYS Number:

747463

MDL number:

MFCD00051734

Assay:

95%

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Properties

Quality Level

100

assay

95%

mp

262-268 °C (dec.) (lit.)

functional group

chloro

SMILES string

COc1cc2nc(Cl)nc(N)c2cc1OC

InChI

1S/C10H10ClN3O2/c1-15-7-3-5-6(4-8(7)16-2)13-10(11)14-9(5)12/h3-4H,1-2H3,(H2,12,13,14)

InChI key

HWIIAAVGRHKSOJ-UHFFFAOYSA-N

Description

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-Heterocyclylpiperazin-1-yl) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.

S F Campbell et al.

Journal of medicinal chemistry, 30(10), 1794-1798 (1987-10-01)

A series of 4-amino-6,7-dimethoxy-2(4-heterocyclylpiperazin-1-yl)quinazolines (3) was prepared and screened for alpha-adrenoceptor affinity and antihypertensive activity. These quinazoline derivatives showed high binding affinity (ca. 10(-10) M) and selectivity (greater than 10,000) for alpha 1-adrenoceptors in vitro, with no relevant activity at

2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.

V A Alabaster et al.

Journal of medicinal chemistry, 30(6), 999-1003 (1987-06-01)

A series of 4-amino-2-(4-carbamoylpiperidino)-6,7-dimethoxyquinazolines (2) were synthesized and evaluated for alpha-adrenoceptor affinity and antihypertensive activity. These compounds displayed high binding affinity (Ki, 10(-9)-10(-10) M) and selectivity for alpha 1-adrenoceptors in vitro, and 12, 14, 21-26, and 29 showed similar potency

Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists.

A Leonardi et al.

Journal of medicinal chemistry, 42(3), 427-437 (1999-02-13)

A new series of novel piperazine and non-piperazine derivatives of 2, 4-diamino-6,7-dimethoxyquinazoline was synthesized and evaluated for binding affinity toward alpha1-adrenergic and other G-protein-coupled aminergic receptors. The alpha1-adrenoceptor (AR) subtype selectivity was also investigated for the most interesting compounds. Only

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Global Trade Item Number

SKU	GTIN
518654-25G	04061832544052