532363
(S)-(−)-1,2-Epoxybutane
98%
Synonym(s):
(2S)-Ethyloxirane
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About This Item
Empirical Formula (Hill Notation):
C4H8O
CAS Number:
Molecular Weight:
72.11
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Assay:
98%
InChI
1S/C4H8O/c1-2-4-3-5-4/h4H,2-3H2,1H3/t4-/m0/s1
SMILES string
CC[C@H]1CO1
InChI key
RBACIKXCRWGCBB-BYPYZUCNSA-N
assay
98%
optical activity
[α]20/D −10°, neat
refractive index
n20/D 1.386 (lit.)
bp
63 °C (lit.)
density
0.837 g/mL at 25 °C (lit.)
functional group
ether
Quality Level
Related Categories
Application
(S)-(−)-1,2-Epoxybutane can be used:
- As a starting material to prepare (+)- and (−)-homononactic acids, which are used as intermediates in the total synthesis of a cyclic antibiotic tetranactin.
- To prepare a chiral phosphorus synthon, which is applicable in the synthesis of phytoprostane B1 type I.
- To prepare Eu3+-based precatalysts applicable in the Mukaiyama Aldol reaction in water.
Legal Information
Manufactured under license by Sterling Pharma Solutions Limited, using Jacobsen HKR technology.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
10.0 °F - closed cup
flash_point_c
-12.2 °C - closed cup
ppe
Faceshields, Gloves, Goggles
Regulatory Information
危险化学品
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Synthesis, spectroscopic characterization, and reactivity of water-tolerant Eu3+-based precatalysts
Averill DJ and Allen MJ
Inorganic Chemistry, 53(12), 6257-6263 (2014)
Synthesis of (+)-and (−)-homononactic acid from (S)-1, 2-epoxybutane. Total synthesis of tetranactin by ′reverse coupe du roi′
Schmidt U and Werner J
Journal of the Chemical Society. Chemical Communications, 996-998 (1986)
A flexible synthesis of the phytoprostanes B1 type I and II
El Fangour S, et al.
The Journal of Organic Chemistry, 70(3), 989-997 (2005)
D Weinstein et al.
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Based on the findings of Nagao et al [1978] that phenacetin is negative in the standard Ames test with Aroclor induced rat S-9 and positive with hamster S-9, the test was performed with a mixture of rat/hamster S-9. Phenacetin was
D Henschler et al.
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Previous analytical studies of industrial samples of trichloroethylene (TRI) have revealed the presence of mutagenic and carcinogenic epoxides which, it was proposed, might be responsible for the carcinogenicity of such samples, as demonstrated with mice in other laboratories. To test
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