All Photos(1)
About This Item
Linear Formula:
BrC6H3(Cl)F
CAS Number:
Molecular Weight:
209.44
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
98%
refractive index
n20/D 1.556 (lit.)
bp
91-92 °C/20 mmHg (lit.)
density
1.678 g/mL at 25 °C (lit.)
SMILES string
Fc1cc(Cl)ccc1Br
InChI
1S/C6H3BrClF/c7-5-2-1-4(8)3-6(5)9/h1-3H
InChI key
FPNVMCMDWZNTEU-UHFFFAOYSA-N
General description
1-Bromo-4-chloro-2-fluorobenzene is a polyhalo substituted benzene. It undergoes Suzuki coupling with 2-cyanoarylboronic esters to form the corresponding biphenyls. These biphenyls are the precursors for synthesizing 6-substituted phenanthridines.† The enthalpy of vaporization at boiling point (467.15K) of 1-bromo-4-chloro-2-fluorobenzene is 40.737kjoule/mol.{4}
Application
1-Bromo-4-chloro-2-fluorobenzene may be used in the preparation of benzonorbornadiene derivative. It may also be used as a starting material in the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
198.0 °F - closed cup
Flash Point(C)
92.2 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service