532851
Methyl 2-iodobenzoate
97%
Synonym(s):
Methyl o-iodobenzoate
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About This Item
Linear Formula:
IC6H4CO2CH3
CAS Number:
Molecular Weight:
262.04
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
210-243-6
MDL number:
Assay:
97%
InChI key
BXXLTVBTDZXPTN-UHFFFAOYSA-N
InChI
1S/C8H7IO2/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5H,1H3
SMILES string
COC(=O)c1ccccc1I
assay
97%
refractive index
n20/D 1.604 (lit.)
bp
149-150 °C/10 mmHg (lit.)
density
1.784 g/mL at 25 °C (lit.)
functional group
ester, iodo
Quality Level
Related Categories
General description
Methyl 2-iodobenzoate can be prepared from 2-iodobenzoic acid via esterification. It undergoes cobalt-catalyzed cyclization with aldehydes to form phthalide derivatives. The microbial dihydroxylation of methyl 2-iodobenzoate forms a nonracemic iodocyclohexene carboxylate intermediate. This intermediate forms the precursor for preparing kibdelone C.
Application
Methyl 2-iodobenzoate may be used in the preparation of:
- N-substituted 4-methylene-3,4-dihydro-1(2H)-isoquinolin-1-ones
- methyl diphenylacetylene-2-carboxylate
- methyl 2-heptynylphenylbenzoate
- (E)-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic acid methyl ester
- 4-(2-carbomethoxyphenyl)-3-(1-methylethoxy)cyclobut-3-ene-1,2-dione
- 3-(2-carbomethoxyphenyl)-4-methylcyclobuten-3-ene-1,2-dione 2-(ethylene acetal)
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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An efficient synthesis of LTD4 antagonist L-699,392.
The Journal of Organic Chemistry, 58(14), 3731-3735 (1993)
A short synthesis of nonracemic iodocyclohexene carboxylate fragment for kibdelone and congeners.
Endoma-Arias MAA and Hudlicky T.
Tetrahedron Letters, 52(49), 6632-6634 (2011)
3-Stannylcyclobutenediones as nucleophilic cyclobutenedione equivalents. Synthesis of substituted cyclobutenediones and cyclobutenedione monoacetals and the beneficial effect of catalytic copper iodide on the Stille reaction.
Liebeskind LS and Fengl RW.
The Journal of Organic Chemistry, 55(19), 5359-5364 (1990)
Palladium homogeneous and supported catalysis: synthesis of functional acetylenics and cyclisation to heterocycles.
Villemin D and Goussu D.
Heterocycles, 29(7), 1255-1261 (1989)
Highly Efficient Cyclization of o?Iodobenzoates with Aldehydes Catalyzed by Cobalt Bidentate Phosphine Complexes: A Novel Entry to Chiral Phthalides.
Chang HT, et al.
Chemistry (Weinheim An Der Bergstrasse, Germany), 13(15), 4356-4363 (2007)
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