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534498

4-Piperidinopiperidine

Name: 4-Piperidinopiperidine
Brand: ALDRICH

97%

Synonym(s):

1,4′-Bipiperidine

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₂₀N₂

CAS Number:

4897-50-1

Molecular Weight:

168.28

NACRES:

NA.22

PubChem Substance ID:

24878040

UNSPSC Code:

12352100

EC Number:

225-522-8

MDL number:

MFCD00006475

Assay:

97%

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Properties

Quality Level

200

assay

97%

mp

64-66 °C (lit.)

storage temp.

−20°C

SMILES string

C1CCN(CC1)C2CCNCC2

InChI

1S/C10H20N2/c1-2-8-12(9-3-1)10-4-6-11-7-5-10/h10-11H,1-9H2

InChI key

QDVBKXJMLILLLB-UHFFFAOYSA-N

Gene Information

rat ... Grin2a(24409)

Description

Application

Medicinal chemistry reagent.

Reactant for synthesis of:
Arylthiadiazole H3 antagonists
Water-soluble N-mustards as anticancer agents
Antitubercular drugs
Vasopressin1b receptor antagonists
MDR modulators
Selective Norepinephrine transporter inhibitors

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

Janice L Hyatt et al.

Chemico-biological interactions, 157-158, 247-252 (2005-11-01)

CPT-11 (irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) is an anticancer prodrug that has been approved for the treatment of colon cancer. It is a member of the camptothecin class of drugs and activation to the active metabolite SN-38, is mediated by carboxylesterases (CE). SN-38

Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate.

Yuqiang Wang et al.

Bioorganic & medicinal chemistry, 13(19), 5592-5599 (2005-08-09)

We have synthesized a conjugate of cis-4,7,10,13,16,19-docosahexenoic acid (DHA) and 10-hydroxycamptothecin (HCPT), DHA-HCPT. The antitumor activity of DHA-HCPT was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia, Lewis lung carcinoma, and colon

Synthesis and structure-activity relationships of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine derivatives: novel arginine vasopressin antagonists.

Hidetsura Cho et al.

Journal of medicinal chemistry, 47(1), 101-109 (2003-12-30)

A variety of novel heterocyclic compounds having thienoazepine, pyrroloazepine, furoazepine, and thienodiazepine skeletons were synthesized, most of which exhibited potent antagonism of [(3)H]-AVP specific binding in assays using rat liver (V1), rat kidney (V2), human platelet plasma membranes, and recombinant

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Global Trade Item Number

SKU	GTIN
534498-10G	04061833045879
534498-50G	04061833045886