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Merck
CN

538515

Supelco

Fenbufen

96%

Synonym(s):

γ-Oxo-(1,1′-biphenyl)-4-butanoic acid

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About This Item

Linear Formula:
C6H5C6H4CO(CH2)2CO2H
CAS Number:
36330-85-5
Molecular Weight:
254.28
EC Number:
252-979-0
MDL number:
MFCD00056701
UNSPSC Code:
41121813
PubChem Substance ID:
329758009

Key Documents

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Assay

96%

mp

184-187 °C (lit.)

SMILES string

OC(=O)CCC(=O)c1ccc(cc1)-c2ccccc2

InChI

1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)

InChI key

ZPAKPRAICRBAOD-UHFFFAOYSA-N

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
15616AO

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A E Sloboda et al.
Arzneimittel-Forschung, 30(4A), 716-721 (1980-01-01)
gamma-Oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) was shown to be an orally and parenterally effective nonsteroidal antiinflammatory, analgesic and antipyretic agent in a variety of animal species. Like other clinically active antiinflammatory drugs such as acetylsalicylic acid (ASA), indometacin and phenylbutazone, fenbufen has
Marta Cruz-Vera et al.
Journal of chromatography. A, 1202(1), 1-7 (2008-07-18)
Dynamic liquid-phase microextraction (dLPME) using an ionic liquid as acceptor phase is proposed for the determination of six non-steroidal anti-inflammatory drugs (NSAIDs) in human urine samples for the first time. The extraction is carried out in a simple and automatic
L Rodriguez et al.
International journal of pharmaceutics, 183(2), 133-143 (1999-06-11)
A new atomizer that operates with ultrasonic energy is described. This apparatus is intended to obtain microparticulate drug delivery systems through spray-congealing or spray-drying technologies. In this work, some experimental results are reported on model systems submitted to spray-congealing. The
Daniel Carriazo et al.
Journal of pharmaceutical sciences, 99(8), 3372-3380 (2010-03-17)
This work reports the immobilization of Fenbufen, a nonsteroidal anti-inflammatory drug, into two different hexagonal mesoporous silicas (MCM-41) which exhibit some differences in terms of morphology and pore size, and their behavior as systems for sustained release at pH 7.5.
F Kamali et al.
Antimicrobial agents and chemotherapy, 42(5), 1256-1258 (1998-05-21)
The potential effects of concurrent administration of fenbufen and ciprofloxacin on central nervous system activity in healthy young subjects were investigated by electroencephalography (EEG). Visual analog scales (VAS) were used to assess subjective measures of concentration, vigilance, tension, and irritability.
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