545686
3-Chloro-2-methylbenzenesulfonyl chloride
97%
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Linear Formula:
ClC6H3(CH3)SO2Cl
CAS Number:
Molecular Weight:
225.09
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
Assay:
97%
InChI
1S/C7H6Cl2O2S/c1-5-6(8)3-2-4-7(5)12(9,10)11/h2-4H,1H3
SMILES string
Cc1c(Cl)cccc1S(Cl)(=O)=O
InChI key
ZSIYKAQPQRTBPF-UHFFFAOYSA-N
assay
97%
mp
71-74 °C (lit.)
Application
3-Chloro-2-methylbenzenesulfonyl chloride may be used in the synthesis of ethyl [6-(3-chloro-2-methyl-benzenesulfonyl-amino)-pyridin-2-yl]-acetate and ethyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate.
General description
3-Chloro-2-methylbenzenesulfonyl chloride is an aryl sulfonyl chloride derivative.
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Tjeerd Barf et al.
Journal of medicinal chemistry, 45(18), 3813-3815 (2002-08-23)
Novel antidiabetic arylsulfonamidothiazoles are presented that exert action through selective inhibition of the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme, thereby attenuating hepatic gluconeogenesis. The diethylamide derivative 2a was shown to potently inhibit human 11beta-HSD1 (IC(50) = 52 nM), whereas the
P G De Benedetti et al.
Journal of medicinal chemistry, 30(3), 459-464 (1987-03-01)
A set of 25 4'-, eight 2',4'-, and five 2',4',6'-substituted 4-aminodiphenyl sulfones were tested for their inhibitory activity on dihydropteroate synthase of Escherichia coli. Linear regression analysis shows that enzymic inhibition indices correlate well with both quantum chemical and spectroscopic
Michael Siu et al.
Bioorganic & medicinal chemistry letters, 19(13), 3493-3497 (2009-05-29)
N-(Pyridin-2-yl) arylsulfonamides are identified as inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), an enzyme that catalyzes the reduction of the glucocorticoid cortisone to cortisol. Dysregulation of glucocorticoids has been implicated in the pathogenesis of diabetes and the metabolic syndrome. In
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service