545864
(S)-(−)-Aminoglutethimide
97%
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About This Item
Empirical Formula (Hill Notation):
C13H16N2O2
CAS Number:
Molecular Weight:
232.28
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
Assay:
97%
SMILES string
CC[C@]1(CCC(=O)NC1=O)c2ccc(N)cc2
InChI
1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)/t13-/m0/s1
InChI key
ROBVIMPUHSLWNV-ZDUSSCGKSA-N
assay
97%
optical activity
[α]20/D −160°, c = 1 in methanol
mp
115.5-119.5 °C (lit.)
Quality Level
Gene Information
human ... CYP17A1(1586), CYP19A1(1588)
Related Categories
Application
(S)-(−)-Aminoglutethimide can be used:
- As an internal standard in the separation of the pyridoglutethimide enantiomers using the HPLC technique.
- In the study of steroid hormones role on human cytomegalovirus replication in adrenocortical cells.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
监管及禁止进口产品
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Stereoselective determination of pyridoglutethimide enantiomers in serum with a chiral cellulose-based high-performance liquid chromatographic column using solid phase extraction and UV detection
Hefnawy MM
Journal of Pharmaceutical and Biomedical Analysis, 31(5), 999-1005 (2003)
Marta Trevisan et al.
Journal of cellular physiology, 221(3), 629-641 (2009-08-19)
Following our recent findings on the presence of human cytomegalovirus (HCMV) in the normal human adrenal cortex and in adrenocortical tumors, especially in cortisol-secreting tumors, aim of the present study was to investigate the direct effects of HCMV infection on
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