548081
2,4-Difluorobenzenesulfonyl chloride
97%
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About This Item
Linear Formula:
F2C6H3SO2Cl
CAS Number:
Molecular Weight:
212.60
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
InChI
1S/C6H3ClF2O2S/c7-12(10,11)6-2-1-4(8)3-5(6)9/h1-3H
SMILES string
Fc1ccc(c(F)c1)S(Cl)(=O)=O
InChI key
FJSAJUXIHJIAMD-UHFFFAOYSA-N
assay
97%
refractive index
n20/D 1.518 (lit.)
bp
236-237 °C (lit.)
density
1.581 g/mL at 25 °C (lit.)
functional group
fluoro
General description
2,4-Difluorobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative.
Application
2,4-Difluorobenzenesulfonyl chloride may be used in the preparation of 2,4-difluoro-N,N-dimethylbenzenesulfonamide, a precursor for poly(aryl ether sulfonamide)s.
It may be used in the preparation of the following benzenesulfonamide quinoline derivatives with potent anti-HIV-1 (human immunodeficiency virus type 1) activity:
It may be used in the preparation of the following benzenesulfonamide quinoline derivatives with potent anti-HIV-1 (human immunodeficiency virus type 1) activity:
- 2,4-difluoro-N-methyl-N-(quinolin-8-yl)benzenesulfonamide
- N-ethyl-2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide
- 2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
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Sulfonamide as an Activating Group for the Synthesis of Poly (aryl ether sulfonamide) s by Nucleophilic Aromatic Substitution.
Rebeck NT and Knauss DM.
Macromolecules, 44(17), 6717-6723 (2011)
Fudi Zhong et al.
Organic & biomolecular chemistry, 13(6), 1792-1799 (2014-12-17)
Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this study, we have screened a commercial library and identified the
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