548146
3-(Trifluoromethyl)benzamide
98%
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About This Item
Linear Formula:
CF3C6H4CONH2
CAS Number:
Molecular Weight:
189.13
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
217-289-6
MDL number:
Assay:
98%
InChI key
XBGXGCOLWCMVOI-UHFFFAOYSA-N
InChI
1S/C8H6F3NO/c9-8(10,11)6-3-1-2-5(4-6)7(12)13/h1-4H,(H2,12,13)
SMILES string
NC(=O)c1cccc(c1)C(F)(F)F
assay
98%
mp
124-127 °C (lit.)
General description
3-(Trifluoromethyl)benzamide can be prepared from 1-bromo-3-trifluoromethylbenzene via palladium-catalyzed aminocarbonylation with formamide. It forms the core moiety of N-[(substituted 1H-imidazol-1-yl)propyl]benzamides, with potential as antihypertensive agents.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl) alkyl] aryl amides and N-[(1H-1, 2, 4-triazol-1-yl) alkyl] aryl amides.
Wright Jr WB, et al.
Journal of Medicinal Chemistry, 29(4), 523-530 (1986)
Weinreb SM.
Science of Synthesis: Houben-Weyl Methods of Molecular Transformations, 21, 126-126 (2014)
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