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55100

8-Quinolinol hemisulfate salt

Name: 8-Quinolinol hemisulfate salt
Brand: ALDRICH

≥98.0% (dry substance, T), yellow

Synonym(s):

8-Hydroxyquinoline hemisulfate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₄N₂O₂ · H₂SO₄

CAS Number:

134-31-6

Molecular Weight:

388.39

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

57651498

EC Number:

205-137-1

Beilstein/REAXYS Number:

3760550

MDL number:

MFCD00013095

Assay:

≥98.0% (dry substance, T)

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Properties

description

C₉H₇NO · ½H₂SO₄ (Linear Formula)

assay

≥98.0% (dry substance, T)

impurities

~5% water

color

yellow

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes, enzyme | inhibits

SMILES string

OS(O)(=O)=O.Oc1cccc2cccnc12.Oc3cccc4cccnc34

InChI

1S/2C9H7NO.H2O4S/c2*11-8-5-1-3-7-4-2-6-10-9(7)8;1-5(2,3)4/h2*1-6,11H;(H2,1,2,3,4)

InChI key

YYVFXSYQSOZCOQ-UHFFFAOYSA-N

Description

General description

Chemical structure: quinolone

Application

8-Quinolinol hemisulfate salt (8-OHQ) may be used in the preparation of Cu[8-OHQ]₂, which shows proteasome-inhibitory activity.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells.

Kenyon G Daniel et al.

Biochemical pharmacology, 67(6), 1139-1151 (2004-03-10)

Here we report that organic copper complexes can potently and selectively inhibit the chymotrypsin-like activity of the proteasome in vitro and in vivo. Several copper compounds, such as NCI-109268 and bis-8-hydroxyquinoline copper(II) [Cu(8-OHQ)(2)], can inhibit the chymotrypsin-like activity of purified

Cooperative assembly of Zn cross-linked artificial tripeptides with pendant hydroxyquinoline ligands.

Meng Zhang et al.

Inorganic chemistry, 51(21), 11315-11323 (2012-10-09)

An artificial peptide with three pendant hydroxyquinoline (hq) ligands on a palindromic backbone was designed and used to form multimetallic assemblies. Reaction of the tripeptide with zinc acetate led to a highly fluorescent tripeptide duplex with three Zn(II) coordinative cross-links.

Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation.

Saverio Tardito et al.

Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)

This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and

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Global Trade Item Number

SKU	GTIN
55100-100G-F	04061832577159
55100-500G-F	04061833440544