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55100

8-Quinolinol hemisulfate salt

Name: 8-Quinolinol hemisulfate salt
Brand: ALDRICH

≥98.0% (dry substance, T), yellow

Synonym(s):

8-Hydroxyquinoline hemisulfate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₄N₂O₂ · H₂SO₄

CAS Number:

134-31-6

Molecular Weight:

388.39

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

57651498

EC Number:

205-137-1

Beilstein/REAXYS Number:

3760550

MDL number:

MFCD00013095

Assay:

≥98.0% (dry substance, T)

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Properties

description

C₉H₇NO · ½H₂SO₄ (Linear Formula)

assay

≥98.0% (dry substance, T)

impurities

~5% water

color

yellow

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes, enzyme | inhibits

SMILES string

OS(O)(=O)=O.Oc1cccc2cccnc12.Oc3cccc4cccnc34

InChI

1S/2C9H7NO.H2O4S/c2*11-8-5-1-3-7-4-2-6-10-9(7)8;1-5(2,3)4/h2*1-6,11H;(H2,1,2,3,4)

InChI key

YYVFXSYQSOZCOQ-UHFFFAOYSA-N

Description

General description

Chemical structure: quinolone

Application

8-Quinolinol hemisulfate salt (8-OHQ) may be used in the preparation of Cu[8-OHQ]₂, which shows proteasome-inhibitory activity.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells.

Kenyon G Daniel et al.

Biochemical pharmacology, 67(6), 1139-1151 (2004-03-10)

Here we report that organic copper complexes can potently and selectively inhibit the chymotrypsin-like activity of the proteasome in vitro and in vivo. Several copper compounds, such as NCI-109268 and bis-8-hydroxyquinoline copper(II) [Cu(8-OHQ)(2)], can inhibit the chymotrypsin-like activity of purified

Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation.

Saverio Tardito et al.

Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)

This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and

Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.

Erik H J G Aarntzen et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 19(6), 1525-1533 (2013-02-06)

Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy

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Global Trade Item Number

SKU	GTIN
55100-100G-F	04061832577159
55100-500G-F	04061833440544