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About This Item
Empirical Formula (Hill Notation):
C18H14N2O2 · H2SO4
CAS Number:
Molecular Weight:
388.39
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
205-137-1
Beilstein/REAXYS Number:
3760550
MDL number:
Assay:
≥98.0% (dry substance, T)
description
C9H7NO · ½H2SO4 (Linear Formula)
assay
≥98.0% (dry substance, T)
impurities
~5% water
color
yellow
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
OS(O)(=O)=O.Oc1cccc2cccnc12.Oc3cccc4cccnc34
InChI
1S/2C9H7NO.H2O4S/c2*11-8-5-1-3-7-4-2-6-10-9(7)8;1-5(2,3)4/h2*1-6,11H;(H2,1,2,3,4)
InChI key
YYVFXSYQSOZCOQ-UHFFFAOYSA-N
General description
Chemical structure: quinolone
Application
8-Quinolinol hemisulfate salt (8-OHQ) may be used in the preparation of Cu[8-OHQ]2, which shows proteasome-inhibitory activity.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Kenyon G Daniel et al.
Biochemical pharmacology, 67(6), 1139-1151 (2004-03-10)
Here we report that organic copper complexes can potently and selectively inhibit the chymotrypsin-like activity of the proteasome in vitro and in vivo. Several copper compounds, such as NCI-109268 and bis-8-hydroxyquinoline copper(II) [Cu(8-OHQ)(2)], can inhibit the chymotrypsin-like activity of purified
Meng Zhang et al.
Inorganic chemistry, 51(21), 11315-11323 (2012-10-09)
An artificial peptide with three pendant hydroxyquinoline (hq) ligands on a palindromic backbone was designed and used to form multimetallic assemblies. Reaction of the tripeptide with zinc acetate led to a highly fluorescent tripeptide duplex with three Zn(II) coordinative cross-links.
Saverio Tardito et al.
Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)
This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 55100-100G-F | 04061832577159 |
| 55100-500G-F | 04061833440544 |
