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Merck
CN

552402

1-Bis(4-fluorophenyl)methyl piperazine

97%

Synonym(s):

1-(4,4′-Difluorobenzhydryl)piperazine

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About This Item

Empirical Formula (Hill Notation):
C17H18F2N2
CAS Number:
27469-60-9
Molecular Weight:
288.34
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24879266
EC Number:
248-476-0
Beilstein/REAXYS Number:
620754
MDL number:
MFCD00038660
Assay:
97%

Key Documents

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Product Name

1-Bis(4-fluorophenyl)methyl piperazine, 97%

InChI key

TTXIFFYPVGWLSE-UHFFFAOYSA-N

InChI

1S/C17H18F2N2/c18-15-5-1-13(2-6-15)17(21-11-9-20-10-12-21)14-3-7-16(19)8-4-14/h1-8,17,20H,9-12H2

SMILES string

Fc1ccc(cc1)C(N2CCNCC2)c3ccc(F)cc3

assay

97%

mp

88-92 °C (lit.)

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Application

1-Bis(4-fluorophenyl)methyl piperazine may be used to synthesize 1-[bis(4-fluorophenyl)methyl]-4-[3-[(N-ethoxycarbonyl-N-phenyl)amino]-2-hydroxypropyl]piperazine and (R, S) 3-[4-(bis(4-fluorophenyl)methyl)piperazin-1-yl]dihydrofuran-2(3H)-one.

General description

1-Bis(4-fluorophenyl)methyl piperazine is formed during the synthesis of flunarizine. Its crystals exhibits monoclinic crystal system and space group P21/c.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV7072
MKCN9118
MKCK4835
07801BE
04808CO

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1-[Bis (4-fluorophenyl) methyl] piperazine.
Dayananda AS, et al.
Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials, 68(9), o2817-o2817 (2012)
Syntheses of novel diphenyl piperazine derivatives and their activities as inhibitors of dopamine uptake in the central nervous system.
Kimura M, et al.
Bioorganic & Medicinal Chemistry, 11(8), 1621-1630 (2003)
Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors
Kulig K, et al.
European Journal of Medicinal Chemistry, 46(1), 183-190 (2011)
Y Yamanaka et al.
Archives of toxicology, 69(6), 391-396 (1995-01-01)
Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory
S Kariya et al.
Research communications in chemical pathology and pharmacology, 78(1), 85-95 (1992-10-01)
The oxidative metabolism of flunarizine [1-[bis(4-fluorophenyl)-methyl]-4-(3-phenyl-2-propenyl)piperazine, FZ] to 1-[bis-(4-fluorophenyl)methyl]piperazine (M-1), 1-[bis(4-fluorophenyl)methyl]-4-[3-(4'-hydroxyphenyl)-2- propenyl]piperazine (M-2) and 4,4'-difluorobenzophenone (M-3) has been studied in liver microsomes of Wistar and Dark Agouti (DA) rats. Kinetic analysis demonstrated a sex difference (male > female) in the

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