557323
o-Toluenesulfonyl chloride
97%
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About This Item
Linear Formula:
CH3C6H4SO2Cl
CAS Number:
Molecular Weight:
190.65
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
205-113-0
MDL number:
Product Name
o-Toluenesulfonyl chloride, 97%
InChI key
HDECRAPHCDXMIJ-UHFFFAOYSA-N
InChI
1S/C7H7ClO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3
SMILES string
Cc1ccccc1S(Cl)(=O)=O
assay
97%
refractive index
n20/D >1.5580 (lit.)
bp
254 °C (lit.)
density
1.320 g/mL at 25 °C (lit.)
Application
o-Toluenesulfonyl chloride may be used in the synthesis of:
- oxazoline
- mesityl o-tolyl sulfone
- allyl o-toluenesulfonate
- 2-methyl-4′-t-butyldiphenyl sulfone
General description
o-Toluenesulfonyl chloride can be synthesized by reacting o-thiocresol in glacial acetic acid with chlorine. It participates in the preparation of 5-chloro-3-phenyl-2,1-benzisoxazole.
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
危险化学品
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Cyclization of Acylaminoalkanols to 2-Oxazolines1.
Boyd RN and Rittner RC.
Journal of the American Chemical Society, 82(8), 2032-2034 (1960)
The Metalation of 4-t-Butyldiphenyl Sulfone with n-Butyllithium1.
Shirley DA and Lehto EA.
Journal of the American Chemical Society, 79(13), 3481-3485 (1957)
Min Wang et al.
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A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles were decorated with glycyrrhetinic acid (GA) to target HepG2 cells. The highly insoluble CPT was derivatized
Asymmetric induction reactions. IV. Palladium-catalyzed asymmetric allylations of chiral enamines bearing phosphine groups.
Hiroi K and Abe J.
Chemical & Pharmaceutical Bulletin, 39(3), 616-621 (1991)
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