557323
o-Toluenesulfonyl chloride
97%
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About This Item
Linear Formula:
CH3C6H4SO2Cl
CAS Number:
Molecular Weight:
190.65
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
205-113-0
MDL number:
Assay:
97%
InChI key
HDECRAPHCDXMIJ-UHFFFAOYSA-N
InChI
1S/C7H7ClO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3
SMILES string
Cc1ccccc1S(Cl)(=O)=O
assay
97%
refractive index
n20/D >1.5580 (lit.)
bp
254 °C (lit.)
density
1.320 g/mL at 25 °C (lit.)
General description
o-Toluenesulfonyl chloride can be synthesized by reacting o-thiocresol in glacial acetic acid with chlorine. It participates in the preparation of 5-chloro-3-phenyl-2,1-benzisoxazole.
Application
o-Toluenesulfonyl chloride may be used in the synthesis of:
- oxazoline
- mesityl o-tolyl sulfone
- allyl o-toluenesulfonate
- 2-methyl-4′-t-butyldiphenyl sulfone
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
危险化学品
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Intramolecular nucleophilic participation. V. The role of the ortho-substituent in the solvolysis of o-nitrobenzhydrl bromide and o-nitrobenzyl tosylate.
Mease AD, et al.
Journal of the American Chemical Society, 90(7), 1797-1801 (1968)
Cyclization of Acylaminoalkanols to 2-Oxazolines1.
Boyd RN and Rittner RC.
Journal of the American Chemical Society, 82(8), 2032-2034 (1960)
The Metalation of 4-t-Butyldiphenyl Sulfone with n-Butyllithium1.
Shirley DA and Lehto EA.
Journal of the American Chemical Society, 79(13), 3481-3485 (1957)
Min Wang et al.
Biomaterials, 261, 120301-120301 (2020-09-02)
Local tumor therapy through injectable biodegradable hydrogels with controlled drug release has attracted much attention recently, due to their easy operation, low side effect and efficiency. However, most of the reported therapeutic hydrogel system showed a lack of biodegradation tracking
Rearrangements of sulfones to sulfinic acids via carbanion intermediates.
Truce WE and Brand WW
The Journal of Organic Chemistry, 35(6), 1828-1833 (1970)
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