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Merck
CN

557390

2-Chloro-4-nitropyridine

97%

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About This Item

Empirical Formula (Hill Notation):
C5H3ClN2O2
CAS Number:
Molecular Weight:
158.54
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
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Product Name

2-Chloro-4-nitropyridine, 97%

InChI

1S/C5H3ClN2O2/c6-5-3-4(8(9)10)1-2-7-5/h1-3H

SMILES string

[O-][N+](=O)c1ccnc(Cl)c1

InChI key

LIEPVGBDUYKPLC-UHFFFAOYSA-N

assay

97%

mp

52-56 °C (lit.)

functional group

chloro
nitro

Quality Level

Application

Starting material used in a tetrabutylammonium salt denitration leading to fluoro-, hydroxy- and methoxypyridines.
2-Chloro-4-nitropyridine may be used to synthesize 2-chloro-4-ethoxypyridine and 4-thiophenoxypyridines.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Diels?Alder cycloadditions of stabilised 2, 3-pyridynes.
Connon SJ and Hegarty AF.
Tetrahedron Letters, 42(4), 735-737 (2001)
Stabilised 2, 3-Pyridyne Reactive Intermediates of Exceptional Dienophilicity.
Connon SJ and Hegarty AF.
European Journal of Organic Chemistry, 16, 3477-3483 (2004)
Scott D Kuduk et al.
Organic letters, 7(4), 577-579 (2005-02-12)
An efficient method for the synthesis of fluoropyridines via the fluorodenitration reaction is reported. The reaction is mediated by tetrabutylammonium fluoride (TBAF) under mild conditions without undue regard to the presence of water. The fluorodenitration is general for 2- or
Y Morisawa et al.
Journal of medicinal chemistry, 23(12), 1376-1380 (1980-12-01)
Eight nitropyridinesulfonamides and pyridinesulfonamide N-oxides as their bioisosteres were prepared and evaluated for anticoccidial activity. Of these compounds, 2-, 4- and 5-nitropyridine-3-sulfonamides and pyridine-2- and -3-sulfonamide N-oxides were found to be active against Eimeria tenella. Thus, the relative positions, ortho

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