557404
2-Chloro-4-methoxypyridine
97%
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About This Item
Empirical Formula (Hill Notation):
C6H6ClNO
CAS Number:
Molecular Weight:
143.57
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
InChI
1S/C6H6ClNO/c1-9-5-2-3-8-6(7)4-5/h2-4H,1H3
SMILES string
COc1ccnc(Cl)c1
InChI key
PMTPFBWHUOWTNN-UHFFFAOYSA-N
assay
97%
refractive index
n20/D 1.5400 (lit.)
bp
224-225 °C (lit.)
density
1.258 g/mL at 25 °C (lit.)
Application
2-Chloro-4-methoxypyridine may be used to synthesize:
- 2-(2′,4′-difluorophenyl)-4-methoxypyridine
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl)pyrimidin-4-yl]methanol
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl) pyrimidin-4-yl]methyl acetate
General description
2-Chloro-4-methoxypyridine can be obtained from the reaction between 2-chloro-4-nitropyridine and sodium methoxide in the presence of dioxane. It can also be prepared starting from 4-methoxy-2(1H)-pyridone and 4-nitropyridine N-oxide.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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Total synthesis of variolin B.
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