557404
2-Chloro-4-methoxypyridine
97%
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About This Item
Empirical Formula (Hill Notation):
C6H6ClNO
CAS Number:
Molecular Weight:
143.57
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
assay
97%
refractive index
n20/D 1.5400 (lit.)
bp
224-225 °C (lit.)
density
1.258 g/mL at 25 °C (lit.)
SMILES string
COc1ccnc(Cl)c1
InChI
1S/C6H6ClNO/c1-9-5-2-3-8-6(7)4-5/h2-4H,1H3
InChI key
PMTPFBWHUOWTNN-UHFFFAOYSA-N
General description
2-Chloro-4-methoxypyridine can be obtained from the reaction between 2-chloro-4-nitropyridine and sodium methoxide in the presence of dioxane. It can also be prepared starting from 4-methoxy-2(1H)-pyridone and 4-nitropyridine N-oxide.
Application
2-Chloro-4-methoxypyridine may be used to synthesize:
- 2-(2′,4′-difluorophenyl)-4-methoxypyridine
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl)pyrimidin-4-yl]methanol
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl) pyrimidin-4-yl]methyl acetate
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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Syntheses, photoluminescence and electroluminescence of some new blue-emitting phosphorescent iridium (III)-based materials.
Laskar IR, et al.
Polyhedron, 24(2), 189-200 (2005)
Total synthesis of variolin B.
Anderson RJ and Morris JC.
Tetrahedron Letters, 42(49), 8697-8699 (2001)
Regan J Anderson et al.
The Journal of organic chemistry, 70(16), 6204-6212 (2005-07-30)
The total synthesis of the marine alkaloid variolin B has been achieved in 8 steps and 17% overall yield, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 259470-25G | 04061838145581 |
| 557404-1G | 04061825744421 |