579602
(R)-(+)-1,2-Dithiolane-3-pentanoic acid
97%
Synonym(s):
(R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid
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About This Item
Empirical Formula (Hill Notation):
C8H14O2S2
CAS Number:
Molecular Weight:
206.33
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
Assay
97%
form
solid
optical activity
[α]20/D +104°, c = 1 in chloroform
mp
48-52 °C (lit.)
SMILES string
OC(=O)CCCC[C@@H]1CCSS1
InChI
1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
InChI key
AGBQKNBQESQNJD-SSDOTTSWSA-N
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Alessandra Antonello et al.
Journal of medicinal chemistry, 48(1), 28-31 (2005-01-07)
To combine in the same molecule alpha(1)-adrenoreceptor blocking and antioxidant properties, compounds 2-5 were designed and synthesized. All compounds were effective alpha(1)-adrenoreceptor antagonists and were tested in both functional and binding assays. In addition, compounds 2 and 5 also displayed
Michela Rosini et al.
Journal of medicinal chemistry, 48(2), 360-363 (2005-01-22)
The coupling of two different pharmacophores, each endowed with different biological properties, afforded the hybrid compound lipocrine (7), whose biological profile was markedly improved relative to those of prototypes tacrine and lipoic acid. Lipocrine is the first compound that inhibits
A S Loginov et al.
Farmakologiia i toksikologiia, 52(4), 78-82 (1989-07-01)
The features of the pharmacokinetics of preparations of alpha-lipoic acid (lipoic acid, thioctacide) as compared with their pharmacodynamic effects were studied in 125 patients with chronic diffuse diseases of the liver of viral and alcohol etiology. After a single administration
D B McCormick
The Journal of nutrition, 130(2S Suppl), 323S-330S (2000-03-18)
Over the span of 40 y and with the participation of over 60 students and postdoctoral colleagues, my laboratory has been able to elucidate numerous aspects of cofactor metabolism and function. Findings have been on the absorption, transport, utilization and
Darren G Burke et al.
International journal of sport nutrition and exercise metabolism, 13(3), 294-302 (2003-12-13)
Alpha-lipoic acid has been found to enhance glucose uptake into skeletal muscle in animal models. Studies have also found that the co-ingestion of carbohydrate along with creatine increases muscle creatine uptake by a process related to insulin-stimulated glucose disposal. The
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