630764
7,8-Dihydroxycoumarin
90%
Synonym(s):
Daphnetin, Daphnetol, Ruixiangsu
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About This Item
Empirical Formula (Hill Notation):
C9H6O4
CAS Number:
Molecular Weight:
178.14
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
207-632-8
MDL number:
InChI key
ATEFPOUAMCWAQS-UHFFFAOYSA-N
InChI
1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
SMILES string
Oc1ccc2C=CC(=O)Oc2c1O
assay
90%
Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Jiaqin Liu et al.
Macromolecular bioscience, 4(5), 520-525 (2004-10-07)
Daphnetin (7,8-dihydroxycoumarin), one of the major bioactive components isolated from Daphne koreane Nakai, has been used in traditional Chinese medicine for the treatment of coagulation disorders. It is also a chelator, an antioxidant and a protein kinase inhibitor. In this
Ziyi Wen et al.
Drug delivery, 16(4), 214-223 (2009-03-13)
The percutaneous absorption properties of daphnetin with chemical penetration enhancers were investigated to explore the feasibility of daphnetin as a candidate for transdermal delivery to treat arthritis. Permeation experiments were carried out in vitro using 2-chamber diffusion cells in isopropyl
Si-Cheng Liang et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(6), 973-980 (2010-02-24)
Daphnetin has been developed as an oral medicine for treatment of coagulation disorders and rheumatoid arthritis in China, but its in vitro metabolism remains unknown. In the present study, the UDP-glucuronosyltransferase (UGT) conjugation pathways of daphnetin were characterized. Two metabolites
Fang Huang et al.
Biomedical and environmental sciences : BES, 19(5), 367-370 (2006-12-28)
To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. DA79 and
Qin Gao et al.
Journal of ethnopharmacology, 120(2), 259-263 (2008-10-07)
Daphnetin was regarded as the mark compound for quality control of Zushima-Pian, a traditional Chinese medicine tablet for treating rheumatoid arthritis (RA). However, no in vivo study on the therapeutic effects of daphnetin for RA has been reported. The adjuvant
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