644927
3-Methylpyrazole-5-carboxylic acid
97%
Synonym(s):
5-Methylpyrazole-3-carboxylic acid, AS057278, MPC
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About This Item
Empirical Formula (Hill Notation):
C5H6N2O2
CAS Number:
Molecular Weight:
126.11
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
97%
form
solid
mp
236-240 °C (lit.)
functional group
carboxylic acid
SMILES string
Cc1cc([nH]n1)C(O)=O
InChI
1S/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9)
InChI key
WSMQKESQZFQMFW-UHFFFAOYSA-N
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General description
3-Methylpyrazole-5-carboxylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carboxylic acid specifically prevents formalin-induced tonic pain.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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M J Holness et al.
The Biochemical journal, 232(1), 255-259 (1985-11-15)
Effects of administration of tri-iodothyronine (T3) on activities of cardiac and renal pyruvate dehydrogenase complex (active form, PDHa) were investigated. In fed rats, T3 treatment did not affect cardiac or renal PDHa activity, although blood non-esterified fatty acid and ketone-body
M J Holness et al.
The Biochemical journal, 241(2), 421-425 (1987-01-15)
The work investigated the mechanisms for modulation of renal and hepatic pyruvate dehydrogenase complex (PDH) activities after carbohydrate re-feeding of 48 h-starved rats, and identified a regulatory role for tri-iodothyronine. Glucose re-feeding decreased blood concentrations of lipid fuels in both
K Credner et al.
Arzneimittel-Forschung, 31(12), 2096-2100 (1981-01-01)
5-Methylpyrazole-3-carboxylic acid forms salts with basically substituted adenine bases of type (4) or (5), which have significantly more lipolysis inhibitory activity than the free acid itself. The substance tested, 6-amino-9-[2-hydroxy-3-(N-methyl-N-2-hydroxyethyl)-aminopropyl]-purine-5-methyl pyrazole-3-carboxylate (16), causes a significant reduction of serum FFA levels
Plasma prostaglandin levels in rats with diabetes mellitus and diabetic ketoacidosis.
L Axelrod et al.
Diabetes, 31(11), 994-1001 (1982-11-01)
In vitro effects of theophylline on insulin receptors in adipocytes: correlation with the lipolytic action of the agent.
H J Steinfelder et al.
Biochemical and biophysical research communications, 104(1), 45-51 (1982-01-15)
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