687324
N-Boc-cis-4-fluoro-L-proline
97%
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About This Item
Empirical Formula (Hill Notation):
C10H16FNO4
CAS Number:
Molecular Weight:
233.24
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
Assay
97%
form
solid
optical activity
[α]22/D −71.0±5°, c = 1 in chloroform
mp
157-161 °C (D)
functional group
carboxylic acid
fluoro
SMILES string
CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1C(O)=O
InChI
1S/C10H16FNO4/c1-10(2,3)16-9(15)12-5-6(11)4-7(12)8(13)14/h6-7H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m0/s1
InChI key
YGWZXQOYEBWUTH-BQBZGAKWSA-N
Application
N-Boc-cis-4-fluoro-L-proline can be used as a substrate in the preparation of:
- α4β2 Receptor ligands bearing pyrrolidine nucleus.
- β-Amino pyrrolidine-2-carbonitrile derivatives as possible dipeptidyl peptidase IV (DPP4) inhibitors.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta [b] pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
Ji X, et al.
European Journal of Medicinal Chemistry, 86(6), 242-256 (2014)
Synthesis and Pharmacological Evaluation of α4β2 Nicotinic Ligands with a 3-Fluoropyrrolidine Nucleus
Tamborini L, et al.
ChemMedChem, 10(6), 1071-1078 (2015)
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