696064
(S)-C3-TunePhos
Synonym(s):
(S)-Bis(diphenylphosphino)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonin
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About This Item
Empirical Formula (Hill Notation):
C39H32O2P2
CAS Number:
Molecular Weight:
594.62
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
InChI
1S/C39H32O2P2/c1-5-16-30(17-6-1)42(31-18-7-2-8-19-31)36-26-13-24-34-38(36)39-35(41-29-15-28-40-34)25-14-27-37(39)43(32-20-9-3-10-21-32)33-22-11-4-12-23-33/h1-14,16-27H,15,28-29H2
InChI key
GTIXSUJKFAATAE-UHFFFAOYSA-N
form
powder
Application
Chiral Quest Phosphine Ligands for Asymmetric Hydrogenation
Reactant for:
Precatalyst for:
Catalyst for:
Reactant for:
- Asymmetric hydrogenation of ketones with TunePhos/diamine/ruthenium complexes
- Stereoselective preparation of arylalkyl esters via enantioselective hydrogenation of enol acetates
Precatalyst for:
- Enantioselective iridium-catalyzed carbonyl allylation from alcohol or aldehyde by transfer hydrogenative coupling of allyl acetate
Catalyst for:
- Enantioselective hydrogenation of a-keto esters to a-hydroxy esters using Ru-tunephos catalysts
Provides comparable or superior enantioselectivities and catalytic abilities to BINAP in Ru-catalyzed asymmetric hydrogenations of β-keto esters, cyclic β-(acylamino)acrylates and a-phthalimide ketones.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Wenjun Tang et al.
Journal of the American Chemical Society, 125(32), 9570-9571 (2003-08-09)
Hydrogenation of a series of cyclic beta-(acylamino)acrylates with tetrasubstituted olefins has been accomplished successfully with the use of Ru catalysts with chiral biaryl ligands such as C3-TunaPhos, and up to over 99% ee's have been achieved. This methodology provides an
Synthesis of chiral bisphosphines with tunable bite angles and their applications in asymmetric hydrogenation of beta-ketoesters.
Z Zhang et al.
The Journal of organic chemistry, 65(19), 6223-6226 (2000-09-16)
Aiwen Lei et al.
Journal of the American Chemical Society, 126(6), 1626-1627 (2004-02-12)
A new type of alpha-phthalimide ketones was hydrogenated in excellent enantioselectivity by using a Ru-(C3-TunePhos) complex as the catalyst. Up to 10 000 turnovers have been achieved in more than 99% ee in the hydrogenation reaction. A dynamic kinetic resolution
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