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About This Item

Empirical Formula (Hill Notation):
C7H6N4O
CAS Number:
Molecular Weight:
162.15
Beilstein:
6826
MDL number:
UNSPSC Code:
12352115
PubChem Substance ID:
NACRES:
NA.22
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form

liquid

reaction suitability

reaction type: Carbonylations

concentration

0.4 M in methylene chloride

refractive index

n20/D 1.434

density

1.303 g/mL at 25 °C

SMILES string

O=C(n1ccnc1)n2ccnc2

InChI

1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H

InChI key

PFKFTWBEEFSNDU-UHFFFAOYSA-N

General description

1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent.

Application

1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) may be used in the following studies:
  • Synthesis of peptides in aqueous solution.
  • Synthesis of isoleucine-5 angiotensin II amide-1.
  • For the activation of the hydroxyl termini of tween toward nucleophilic addition.
  • As coupling reagent for the coupling of prostaglandins and other carboxylic acids to the amino groups of bovine serum albumin.
  • Synthesis of peptide thioesters.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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