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Merck
CN

721042

3-Carboxy-5-nitrophenylboronic acid

Synonym(s):

(3-Carboxy-5-nitrophenyl)boronic acid, 3-(Dihydroxyboryl)-5-nitrobenzoic acid, 3-Borono-5-nitrobenzoic acid, 3-Carboxy-5-nitrobenzeneboronic acid, 5-Carboxy-3-nitrobenzeneboronic acid

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About This Item

Empirical Formula (Hill Notation):
C7H6BNO6
CAS Number:
101084-81-5
Molecular Weight:
210.94
NACRES:
NA.22
PubChem Substance ID:
329763815
UNSPSC Code:
12352103
MDL number:
MFCD00757433

Key Documents

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InChI

1S/C7H6BNO6/c10-7(11)4-1-5(8(12)13)3-6(2-4)9(14)15/h1-3,12-13H,(H,10,11)

SMILES string

OB(O)c1cc(cc(c1)[N+]([O-])=O)C(O)=O

InChI key

WNIFCLWDGNHGMX-UHFFFAOYSA-N

form

solid

mp

248-252 °C

functional group

carboxylic acid
nitro

Quality Level

100

Related Categories

Application

3-Carboxy-5-nitrophenylboronic acid can be used as a reactant to prepare:
  • Biaryl derivatives via Suzuki-Miyaura cross-coupling with aryl and heteroaryl halides via the formation of a C-C bond.
  • 3-Chloro-5-nitrobenzoic acid via copper-catalyzed chlorination reaction.
  • Aryl-clonazepam derivatives by palladium-catalyzed Suzuki Cross-coupling reaction with clonazepam in the presence of Pd as a catalyst.

Reactant for:
  • Copper-catalyzed chlorination
  • Parallel solid-phase synthesis of azabicyclooctylidenemethylbenzamides as μ- and d-opioid agonists

Used for:
  • Immobilization of glucose oxidase and acetylcholinesterase on boronic acid-activated silica surfaces

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV7263
MKCN5316
MKBZ1080V
MKBV8545V
MKBP7091V

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New biaryl-chalcone derivatives of pregnenolone via Suzuki-Miyaura cross-coupling reaction. Synthesis, CYP17 hydroxylase inhibition activity, QSAR, and molecular docking study
Al-Masoudi NA, et al.
Steroids, 101, 43-50 (2015)
Copper-catalyzed chlorination of functionalized arylboronic acids
Wu H and Hynes JJ
Organic Letters, 12(6), 1192-1195 (2010)
Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction
Salman MA Al-Hussein and Abdul-Rida NA
European Journal of Chemistry, 7(2), 152-155 (2016)
Zhuojun Huang et al.
Biomaterials science, 6(9), 2487-2495 (2018-08-03)
We report here the development of hydrogels formed at physiological conditions using PEG (polyethylene glycol) based polymers modified with boronic acids (BAs) as backbones and the plant derived polyphenols ellagic acid (EA), epigallocatechin gallate (EGCG), tannic acid (TA), nordihydroguaiaretic acid

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