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725668

Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated

average Mn 2,000

Synonym(s):

NIPAM polymer, PNIPAM-NHS, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM

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About This Item

Linear Formula:
(C6H11NO)n SCH2CH2COO(C4H4NO2)
NACRES:
NA.23
UNSPSC Code:
12162002
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form

powder

Quality Level

100

mol wt

average Mn 2,000

mp

>300 °C

Application

Novel polymer for development of thermosensitive coated micro/nano materialincluding thermoresponsive polymeric drug delivery systems. The NHS ester functional group can be used to conjugate a variety of biomolecules such as enzymes† to the polymer chain.
PNIPAM-based Smart Surfaces for Cell Sheet Tissue Engineering

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCR6318
MKCM2750
MKCJ2081
MKCF2861
MKBQ8858V

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Articles

Functional Polymers for Biomedical Apps

Microparticles in drug delivery: Study on controlling chitosan microparticle size and distribution, exploring encapsulation of BSA and TPP cross-linker.

Designing Temperature and pH Sensitive NIPAM Based Polymers

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Stimuli-Responsive Materials as Intelligent Drug Delivery Systems

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

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Rzaev, Z.M.O.; Dincer, S.; Piskin, E.
Progress in Polymer Science, 32, 534-534 (2007)
K Fujimoto et al.
Biomacromolecules, 1(4), 515-518 (2001-11-17)
We report a novel drug delivery system for apoptosis induction by a "smart" polymer vehicle possessing thermosensitivity and bioaffinity. The polymer chain was prepared by copolymerization of N-isopropylacrylamide and N-methacryloyloxysuccinimide. Cell-adhesive RGDS peptide was conjugated with the copolymer as a
Hua Wei et al.
Biomaterials, 28(1), 99-107 (2006-09-09)
A four-arm star block copolymer, comprised of a hydrophobic PMMA arm and an average of three hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) arms were designed and synthesized from the molecular level. The amphiphilic star block copolymer is capable of self-assembling into micelles in
View All Related Papers

Global Trade Item Number

SKUGTIN
725668-5G04061833331095
725668-1G04061826644560