746223
Maleimide-PEG2-succinimidyl ester
≥95%
Synonym(s):
3-[2-[2-[[3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]propanoic acid 2,5-dioxo-1-pyrrolidinyl ester, Maleimide-PEG2-NHS
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About This Item
Empirical Formula (Hill Notation):
C18H23N3O9
CAS Number:
Molecular Weight:
425.39
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥95%
Form:
solid
Quality Level
assay
≥95%
form
solid
reaction suitability
reaction type: Pegylations, reagent type: cross-linking reagent
mp
92-94 °C
functional group
NHS ester, maleimide
storage temp.
−20°C
SMILES string
O=C(N1CCC(NCCOCCOCCC(ON(C(CC2)=O)C2=O)=O)=O)C=CC1=O
InChI
1S/C18H23N3O9/c22-13(5-8-20-14(23)1-2-15(20)24)19-7-10-29-12-11-28-9-6-18(27)30-21-16(25)3-4-17(21)26/h1-2H,3-12H2,(H,19,22)
InChI key
TZPDZOJURBVWHS-UHFFFAOYSA-N
Application
Heterobifunctional crosslinker with short ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 17.6 angstroms.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Sinem K Saka et al.
Nature biotechnology, 37(9), 1080-1090 (2019-08-21)
Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity and throughput. Here we report immunostaining with signal amplification by exchange reaction (Immuno-SABER), which achieves highly multiplexed signal amplification via DNA-barcoded antibodies and orthogonal DNA concatemers generated
Sabrina Simoncelli et al.
Cell reports, 33(12), 108523-108523 (2020-12-29)
Elucidating the mechanisms that controlled T cell activation requires visualization of the spatial organization of multiple proteins on the submicron scale. Here, we use stoichiometrically accurate, multiplexed, single-molecule super-resolution microscopy (DNA-PAINT) to image the nanoscale spatial architecture of the primary inhibitor
Nirakar Basnet et al.
Nature cell biology, 20(10), 1172-1180 (2018-09-27)
Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 746223-50MG | 04061832890340 |
| 746223-250MG | 04061833241110 |