760900
Poly(ethylene glycol), 4 acetylene dendron, generation 1
average Mn 6,300
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About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
description
acetylene surface groups
form
solid
mol wt
PEG average Mn 6,000 (n~130; esterified with 4 acetylene groups)
average Mn 6,300
feature
generation 1
no. Surface Groups
4
functional group
alkyne
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General description
Dendrimers and dendrons are symmetrically branched polymer structures that possess a well-defined spatial distribution of functional groups. Dendrimers are chemically modified by attaching poly ethylene glycol (PEG) to increase its solubility and prolong circulation half-life. “Clickable groups”, such as primary acetylenes, can be introduced to the mono dispersed dendritic structures, using click chemistry.
Application
Used as an efficient drug delivery system.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Just Click It: Undergraduate Procedures W for the Copper(I)-Catalyzed Formation of 1,2,3-Triazoles from Azides and Terminal Acetylenes
Sharpless WD, et al.
Journal of Chemical Education, 82(12) (2005)
Biocompatible Dendritic Building Blocks for Advanced Biomedical Reasearch
Michael Malkoch and Andreas M Nystrom
Material Matters, 7(3), 47-49 null
Huiyuan Li et al.
Molecules (Basel, Switzerland), 18(8), 9797-9817 (2013-08-21)
Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly used to construct diverse chemotypes
Degradable Poly (ethylene glycol) hydrogels for 2 D and 3D cell culture
Andrea M Kasko
Material Matters, 6 (3), 67-75 null
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