760935
Poly(ethylene glycol), 4 acetylene dendron, generation 1
average Mn 20,000
Synonym(s):
Bis-MPA poly(ethylene glycol), Bis[2,2-bis(hydroxymethyl)propanoic acid] PEG, Dendron functionalized PEG acetylene, generation 1, PEG-20,000, PFD-G1-PEG20k-Acetylene
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About This Item
NACRES:
NA.23
UNSPSC Code:
12162002
description
esterified with 4 acetylene groups
form
solid
mol wt
PEG average Mn 20,000 (n~450), average Mn 20,000
feature
generation 1
no. Surface Groups
4
mp
56-60
functional group
alkyne
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General description
Dendrimers and dendrons are symmetrically branched polymer structures that possess a well-defined spatial distribution of functional groups. Dendrimers are chemically modified by attaching poly ethylene glycol (PEG) molecule to increase its solubility and prolong circulation half-life."Clickable groups", such as primary acetylenes, are introduced to the mono dispersed dendritic structures, using "click" chemistry. These acetylene groups, attached to Bis-MPA based dendrons, allow it to form the conjugates with bioactive moieties such as carbohydrate, fluorescent dyes, disaccharides etc.
Application
The proposed uses are
- as an efficient drug delivery system.
- In vitro toxicological studies
- In vivo via radionuclide labeling and optical imaging
- Biosensors
- Dip pen nanolithography
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Applications of Orthogonal, ?click? Chemistries in the synthesis of functional soft materials
Chemical Reviews, 109 (11), 5620-5686 null
Huiyuan Li et al.
Molecules (Basel, Switzerland), 18(8), 9797-9817 (2013-08-21)
Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly used to construct diverse chemotypes
Degradable Poly (ethylene glycol) hydrogels for 2 D and 3D cell culture
Andrea M Kasko
Material Matters, 6 (3), 67-75 null
Biocompatible Dendritic Building Blocks for Advanced Biomedical Reasearch
Michael Malkoch and Andreas M Nystrom
Material Matters, 7(3), 47-49 null
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